ArticleJournal of materials chemistry. B2021
Spatially heterogeneous epidermal growth factor release from microporous annealed particle (MAP) hydrogel for improved wound closure.
Article in Journal of materials chemistry. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Dynamic, Reconfigurable, and Hierarchical Biosynthetic Composites via Collagen Self-Assembly within Highly Crowded Microgel Pastes.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Cell-scale porosity minimizes foreign body reaction and promotes innervated myofiber formation after volumetric muscle loss.NPJ Regenerative medicine · 2025Article
- Engineering the microstructure and spatial bioactivity of MAP scaffolds instructs vasculogenesis in vitro and modifies vessel formation in vivo.Advanced functional materials · 2025Article
- Microporous annealed particle hydrogels in cell culture, tissue regeneration, and emerging application in cancer immunotherapy.American journal of cancer research · 2025Review
- NIPAm Microgels Synthesised in Water: Tailored Control of Particles' Size and Thermoresponsive Properties.Polymers · 2024Article
- Granular Hydrogels for Harnessing the Immune Response.Advanced healthcare materials · 2024Review
- Conjugation of IL-33 to Microporous Annealed Particle Scaffolds Enhances Type 2-Like Immune Responses In Vitro and In Vivo.Advanced healthcare materials · 2024Article
- Impact of Annealing Chemistry on the Properties and Performance of Microporous Annealed Particle Hydrogels.Biomacromolecules · 2024Article
- Endothelial progenitor cells for fabrication of engineered vascular units and angiogenesis induction.Cell proliferation · 2024Review
- Gelatin methacryloyl granular scaffolds for localized mRNA delivery.Aggregate (Hoboken, N.J.) · 2024Article
- Emerging advances in hydrogel-based therapeutic strategies for tissue regeneration.Regenerative therapy · 2023Review
- Single versus dual microgel species for forming guest-host microporous annealed particle PEG-MAL hydrogel.Journal of biomedical materials research. Part A · 2023Article
- Influence of Microgel and Interstitial Matrix Compositions on Granular Hydrogel Composite Properties.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Annealing High Aspect Ratio Microgels into Macroporous 3D Scaffolds Allows for Higher Porosities and Effective Cell Migration.Advanced healthcare materials · 2022Article
- Controlling Particle Fraction in Microporous Annealed Particle Scaffolds for 3D Cell Culture.Journal of visualized experiments : JoVE · 2022Article
- Particle fraction is a bioactive cue in granular scaffolds.Acta biomaterialia · 2022Article
- Delivery of Dissociated Islets Cells within Microporous Annealed Particle Scaffold to Treat Type 1 Diabetes.Advanced therapeutics · 2022Article
- Sticking Together: Injectable Granular Hydrogels with Increased Functionality via Dynamic Covalent Inter-Particle Crosslinking.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- In silico optimization of heparin microislands in microporous annealed particle hydrogel for endothelial cell migration.Acta biomaterialia · 2022Article
- Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold.Journal of visualized experiments : JoVE · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Microporous annealed particle (MAP) hydrogel has been a promising scaffold platform technology to promote immediate tissue integration in injured tissue environments. The addition of growth factors has the potential to accelerate tissue integration and enhance scaffold-mediated healing. Growth factor releasing scaffolds face the translational hurdle of limited solubilized protein shelf stability; however, to address this hurdle we present a lyophilized MAP scaffold which can be effectively rehydrated directly prior to use. Our new approach includes a heterogenous MAP scaffold wherein 5% of the microgels contain immobilized heparin loaded with epidermal growth factor (EGF) at 1 μg mL
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.