Evidence map›Paper›PMID 33998596›Full record

ArticleThe Journal of clinical investigation2021

DACH1 as a multifaceted and potentially druggable susceptibility factor for kidney disease.

Sandra Merscher, Christian Faul

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sandra MerscherKatz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Christian FaulDivision of Nephrology, Department of Medicine, The University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.
University of Alabama at Birmingham · USUniversity of Miami · US

Funding

Crosstalk Between Lipid Droplets and Other Organelles in PodocytesR01DK104753 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FORNONI, ALESSIA · 2015 to 2025
$5.9M
Changes in phosphate metabolism cause pathologic cardiac remodeling in chronic kidney disease (CKD)R01HL145528 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI FAUL, CHRISTIAN, WHITE, KENNETH E · 2019 to 2022
$2.4M
(PQ12) Targeting SMPDL3b to Prevent Radiation-Induced NephrotoxicityR01CA227493 · NCI · UNIVERSITY OF ROCHESTER · PI MARPLES, BRIAN · 2018 to 2022
$2.0M
ACTIVATION OF CARDIAC FGFR4 CAUSES LEFT VENTRICULAR HYPERTROPHYR01HL128714 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FAUL, CHRISTIAN · 2015 to 2019
$1.9M
Hyperphosphatemia Contributes to Systemic Inflammation and Anemia in Chronic Kidney DiseaseR01DK125459 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAUL, CHRISTIAN · 2020 to 2023
$1.5M
SMPDL3b and podocyte insulin signaling in DKDR01DK117599 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FORNONI, ALESSIA · 2018 to 2021
$1.4M
NCI NIH HHS R01 CA227493NHLBI NIH HHS R01 HL128714NHLBI NIH HHS R01 HL145528NIDDK NIH HHS R01 DK104753NIDDK NIH HHS R01 DK117599NIDDK NIH HHS R01 DK125459
6 · The paper itself

Abstract

Kidney diseases affect more than 15% of adults in the US, yet drug development in the kidney field, when compared with that for other common diseases, has been lagging behind. Modifiers that increase the susceptibility to injury and contribute to the pathogenesis and progression of kidney disease include genetic and environmental factors and epigenetic mechanisms. In this issue of the JCI, Cao et al. and Doke et al. independently report the identification of a susceptibility factor called Dachshund homolog 1 (DACH1). Both groups identify an association of reduced DACH1 expression with kidney disease, using different screening approaches, studying different types of human kidney diseases, and using different experimental models, making the fact that both stumbled over the same protein very compelling. Combined, these studies highlight DACH1 as a key safeguard in the kidney, granting various cell types proper function by modulating several molecular pathways.

Indexed as

Kidney DiseasesTranscription FactorsEye ProteinsHumansDACH1 protein, humanEye ProteinsTranscription Factors

Identifiers

PMID33998596
PMCPMC8121511
OpenAlexW3161952662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.