Observational studyJournal of the American Heart Association2021
Risk Stratification of Patients With NonObstructive Coronary Artery Disease Using Resistive Reserve Ratio.
Observational study in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Angiography-based coronary microvascular assessment with and without intracoronary pressure measurements: a systematic review.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Pooled it
- The prognostic value of coronary flow reserve in patients with non-obstructive coronary artery disease and microvascular dysfunction: a systematic review and meta-analysis with focus on imaging modality and sex difference.The international journal of cardiovascular imaging · 2023Pooled it
- Intracoronary physiological indices for coronary microvascular dysfunction: from concept to clinical application.Cardiovascular intervention and therapeutics · 2026Review
- The Diagnostic and Prognostic Impact of Cardiovascular Magnetic Resonance in Ischemic Heart Disease: A Systematic Review.Journal of clinical medicine · 2026Review
- Review
- Altered cardiac-coronary coupling relates to abnormal fractional flow reserve without flow limitation after percutaneous coronary interventions.Physiological reports · 2025Article
- Coronary Microvascular Disease Early After Myocardial Infarction: Diagnostic Approach and Prognostic Value-A Narrative Review.Biomedicines · 2025Review
- The impact of high microvascular resistance on coronary wave energetics depends on coronary microvascular functionality.European heart journal open · 2025Article
- Single-Center Analysis of Soluble TREM2 as a Biomarker in Coronary Microvascular Dysfunction: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Exploring coronary microvascular dysfunction from functional impairment and structural damage.Frontiers in cardiovascular medicine · 2025Review
- The role of coronary microcirculation in heart failure with preserved ejection fraction: An unceasing odyssey.Heart failure reviews · 2025Review
- Prognostic Implications of Resistive Reserve Ratio in Patients With Nonobstructive Coronary Artery Disease With Myocardial Bridging.Journal of the American Heart Association · 2024Article
- Beyond Coronary Artery Disease: Assessing the Microcirculation.Cardiology clinics · 2024Review
- Thrombolysis in Myocardial Infarction Frame Count for Coronary Blood Flow Evaluation during Interventional Diagnostic Procedures.Medicina (Kaunas, Lithuania) · 2023Article
- Coronary Microvascular Disease in Contemporary Clinical Practice.Circulation. Cardiovascular interventions · 2023Review
- Validation of pressure-bounded coronary flow reserve using invasive coronary physiologic assessment.Heart and vessels · 2023Article
- Factors Associated with Impaired Resistive Reserve Ratio and Microvascular Resistance Reserve.Diagnostics (Basel, Switzerland) · 2023Article
- Coronary microvascular dysfunction in heart failure patients.Frontiers in cardiovascular medicine · 2023Review
- Beyond Coronary Artery Disease: Assessing the Microcirculation.Interventional cardiology clinics · 2023Review
- Prognostic value of structural and functional coronary microvascular dysfunction in patients with non-obstructive coronary artery disease; from the multicentre international ILIAS registry.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Background Resistive reserve ratio (RRR), or the ratio of baseline to hyperemic microvascular resistance, has prognostic implications in predicting clinical outcomes in patients with obstructive coronary artery disease. However, its value in patients with angina or ischemia with nonobstructive coronary artery disease is unknown. Methods and Results We included 1692 patients with nonobstructive coronary artery disease who underwent invasive coronary vasoreactivity testing. Abnormal coronary flow reserve (CFR, the ratio of hyperemic and baseline resting flow velocities) and RRR were defined as <2.5 and <2.62, respectively. The mortality rate was marginally higher in patients with abnormal CFR (428 patients [25%]) than those with normal CFR (38 [9%] versus 81 [6%];
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.