Evidence map›Paper›PMID 33998241›Full record

ArticleJournal of the American Heart Association2021

Impact of Uncontrolled Hypertension at 3 Months After Intracerebral Hemorrhage.

Alessandro Biffi, Kay-Cheong Teo, Juan Pablo Castello, Jessica R Abramson, Ian Y H Leung, William C Y Leung, Yujie Wang, Christina Kourkoulis, Evangelos Pavlos Myserlis, Andrew D Warren and 10 more

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05830305 narecruitingnot on this mapstarted 2023, after this paper: background citation

MOBILE Health Intervention in IntraCerebral Hemorrhage Survivors

TypeinterventionalSponsorThe University of Hong KongRan2023 to 2027Enrolled140ConditionsIntracerebral Hemorrhage, HypertensionArmsMobile health intervention
NCT07458880 narecruitingnot on this mapstarted 2026, after this paper: background citation

TRIple Antihypertensive Medication After Intracerebral Hemorrhage for Blood Pressure ConTrol With the TRICH Score

TypeinterventionalSponsorThe University of Hong KongRan2026 to 2030Enrolled140ConditionsIntracerebral HemorrhageArmsExforge HCT® or Three Individual drug amlodipine + valsartan + hydrochlorothiazide
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 3 countries.

Alessandro BiffiDepartment of Neurology Massachusetts General Hospital Boston MA.
Kay-Cheong TeoDepartment of Medicine Queen Mary Hospital LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR.
Juan Pablo CastelloDepartment of Neurology Massachusetts General Hospital Boston MA.
Jessica R AbramsonDepartment of Neurology Massachusetts General Hospital Boston MA.
Ian Y H LeungDepartment of Medicine Queen Mary Hospital LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR.
William C Y LeungDepartment of Medicine Queen Mary Hospital LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR.
Yujie WangDepartment of Medicine Queen Mary Hospital LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR.
Christina KourkoulisDepartment of Neurology Massachusetts General Hospital Boston MA.
Evangelos Pavlos MyserlisDepartment of Neurology Massachusetts General Hospital Boston MA.
Andrew D WarrenDepartment of Neurology Massachusetts General Hospital Boston MA.
Jonathan HenryDepartment of Neurology Massachusetts General Hospital Boston MA.
Koon-Ho ChanDepartment of Medicine Queen Mary Hospital LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR.
Raymond T F CheungDepartment of Medicine Queen Mary Hospital LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR.
Shu-Leong HoDepartment of Medicine Queen Mary Hospital LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR.
Christopher D AndersonDepartment of Neurology Massachusetts General Hospital Boston MA.
M Edip GurolDepartment of Neurology Massachusetts General Hospital Boston MA.
Anand ViswanathanDepartment of Neurology Massachusetts General Hospital Boston MA.
Steven M GreenbergDepartment of Neurology Massachusetts General Hospital Boston MA.
Kui-Kai LauDepartment of Medicine Queen Mary Hospital LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR.
Jonathan RosandDepartment of Neurology Massachusetts General Hospital Boston MA.
Massachusetts General Hospital · USQueen Mary Hospital · CNChinese University of Hong Kong · HK

Funding

Center for Common Disease GeneticsUM1HG008895 · NHGRI · BROAD INSTITUTE, INC. · PI DALY, MARK JOSEPH, GABRIEL, STACEY · 2016 to 2020
$111.2M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FROSCH, MATTHEW P · 1985 to 2018
$42.1M
Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH)U01NS069763 · NINDS · UNIVERSITY OF CINCINNATI · PI ANDERSON, CHRISTOPHER DAVID, DEMEL, STACIE · 2010 to 2024
$34.2M
Genetic&Environment Risk Factors for Hemorrhagic StrokeR01NS036695 · NINDS · UNIVERSITY OF CINCINNATI · PI WOO, DANIEL · 1997 to 2012
$14.1M
Recurrent Hemorrhagic Stroke in Minority PopulationsR01NS093870 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI JONATHAN ROSAND, Amytis Towfighi · 2016 to 2026
$12.3M
Vascular Dysfunction in Cerebral Amyloid AngiopathyR01AG026484 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBERG, STEVEN M · 2005 to 2019
$7.5M
Sequencing Annotation and Functional Analysis in Risk of Intracerebral HemorrhageR01NS103924 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID · 2018 to 2022
$3.4M
Platform for Accelerating Genetic Discovery for Cerebrovascular DiseaseR24NS092983 · NINDS · BROAD INSTITUTE, INC. · PI ROSAND, JONATHAN · 2015 to 2018
$1.2M
Apathy and Depression following Intracerebral HemorrhageK23NS100816 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BIFFI, ALESSANDRO · 2017 to 2021
$1.0M
NHGRI NIH HHS UM1 HG008895NIA NIH HHS P50 AG005134NIA NIH HHS R01 AG026484NINDS NIH HHS K23 NS100816NINDS NIH HHS R01 NS036695NINDS NIH HHS R01 NS093870NINDS NIH HHS R01 NS103924NINDS NIH HHS R24 NS092983NINDS NIH HHS U01 NS069763
6 · The paper itself

Abstract

Background Survivors of intracerebral hemorrhage (ICH) are at high risk for recurrent stroke, which is associated with blood pressure control. Because most recurrent stroke events occur within 12 to 18 months of the index ICH, rapid blood pressure control is likely to be crucial. We investigated the frequency and prognostic impact of uncontrolled short-term hypertension after ICH. Methods and Results We analyzed data from Massachusetts General Hospital (n=1305) and the University of Hong Kong (n=523). We classified hypertension as controlled, undertreated, or treatment resistant at 3 months after ICH and determined the following: (1) the risk factors for uncontrolled hypertension and (2) whether hypertension control at 3 months is associated with stroke recurrence and mortality. We followed 1828 survivors of ICH for a median of 46.2 months. Only 9 of 234 (4%) recurrent strokes occurred before 3 months after ICH. At 3 months, 713 participants (39%) had controlled hypertension, 755 (41%) had undertreated hypertension, and 360 (20%) had treatment-resistant hypertension. Black, Hispanic, and Asian race/ethnicity and higher blood pressure at time of ICH increased the risk of uncontrolled hypertension at 3 months (all

Indexed as

AgedBlood PressureCerebral HemorrhageFemaleFollow-Up StudiesHong KongHumansHypertensionIncidenceMaleRecurrenceRetrospective StudiesSurvival RateTime Factorshypertensionintracerebral hemorrhagestroke

Identifiers

PMID33998241
PMCPMC8483505
OpenAlexW3160106572

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.