ArticleBrain and behavior2021
The associations of increased cerebral small vessel disease with cognitive impairment in neurosyphilis presenting with ischemic stroke.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Reliability and validity of the total cerebral small vessel disease score: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Syphilis and cerebral stroke: a case report and systematic review.Neurological research and practice · 2026Article
- Research progress on the mechanisms of neurosyphilis' impact on cognitive function, early identification, and prevention strategies.Frontiers in neurology · 2025Review
- Review of the mechanism of infection induced cerebral small vessel disease.Frontiers in immunology · 2025Review
- Selective attention function impairment in HIV-negative patients with early forms of neurosyphilis.European journal of medical research · 2024Article
- Establishment and evaluation of a clinical prediction model for cognitive impairment in patients with cerebral small vessel disease.BMC neuroscience · 2024Article
- An Updated Review of Recent Advances in Neurosyphilis.Frontiers in medicine · 2022Review
- Factors Influencing Post-Stroke Cognitive Impairment in Patients with Type 2 Diabetes Mellitus.Clinical interventions in aging · 2022Article
- The associations of increased cerebral small vessel disease with cognitive impairment in neurosyphilis presenting with ischemic stroke.Brain and behavior · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeIschemic stroke is a common clinical feature of neurosyphilis, but its accompanying cognitive decline is often overlooked. The mechanisms of cognitive impairment in neurosyphilis presenting with ischemic stroke are not fully understood. Cerebral small vessel disease (CSVD) was recently shown to predict post-stroke cognitive decline. Therefore, this study aims to validate the correlation between CSVD and cognitive impairment in neurosyphilis presenting with ischemic stroke.
methodsWe enrolled 179 neurosyphilis patients diagnosed as acute ischemic stroke and performed a 12-month cognitive assessment follow-up. CSVD burden was evaluated by neuroimaging markers, including white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), and perivascular spaces (PVS). We performed multivariate logistic regression analysis to determine the association between cognitive decline and total CSVD burden score in neurosyphilis patients.
resultsThe neurosyphilis participants had a significantly higher total CSVD score and lower cognitive function score compared with the syphilis-uninfected patients. Acute cognitive impairment was associated with total CSVD score, extensive microbleeds, and Grade 3 WMHs. After 12-month follow-up, the poor prognosis of post-stroke cognitive impairment was associated with a higher burden of CSVD and extensive microbleeds.
conclusionsCerebral small vessel disease loads in neurosyphilis patients presenting with ischemic stroke are independently associated with acute cognitive impairment and have a prospective value for post-stroke cognitive outcomes.
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