ArticleJournal of applied clinical medical physics2021
Physical and biological beam modeling for carbon beam scanning at Osaka Heavy Ion Therapy Center.
Article in Journal of applied clinical medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
- For ultra-high dose rate carbon-ion irradiation, comparable beam parameters induce the equivalent cell sparing (FLASH) effect.Journal of radiation research · 2026Article
- Influence of nozzle configurations on radiobiological effects in carbon ion radiation therapy estimated using GATE/Geant4.Zeitschrift fur medizinische Physik · 2026Article
- A modified broad beam model for uniformly scanned carbon ion therapy accounting for field inhomogeneities.Scientific reports · 2026Article
- Feasibility and safety of Taipei Veterans General Hospital Heavy Ion Therapy Center: The first carbon-ion irradiation facility in Taiwan.Journal of the Chinese Medical Association : JCMA · 2025Article
- Assessing the robustness of dose distributions in carbon ion prostate radiotherapy using a fast dose evaluation system.Journal of applied clinical medical physics · 2025Article
- Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning.Scientific reports · 2024Article
- Variation of the relative biological effectiveness in the penumbra of ion therapy beams estimated using different microdosimetric approaches.Physics and imaging in radiation oncology · 2024Article
- Validation of robust radiobiological optimization algorithms based on the mixed beam model for intensity-modulated carbon-ion therapy.PloS one · 2023Article
- The Mayo Clinic Florida Microdosimetric Kinetic Model of Clonogenic Survival: Application to Various Repair-Competent Rodent and Human Cell Lines.International journal of molecular sciences · 2022Article
- Article
- Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams.PloS one · 2022Article
- Carbon ion radiotherapy using fiducial markers for prostate cancer in Osaka HIMAK: Treatment planning.Journal of applied clinical medical physics · 2021Article
- Three-dimensional Patient-specific Quality Assurance Using Beam Delivery Log Data for Pencil Beam Scanning Carbon-ion Radiotherapy.In vivo (Athens, Greece)Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have developed physical and biological beam modeling for carbon scanning therapy at the Osaka Heavy Ion Therapy Center (Osaka HIMAK). Carbon beam scanning irradiation is based on continuous carbon beam scanning, which adopts hybrid energy changes using both accelerator energy changes and binary range shifters in the nozzles. The physical dose calculation is based on a triple Gaussian pencil-beam algorithm, and we thus developed a beam modeling method using dose measurements and Monte Carlo simulation for the triple Gaussian. We exploited a biological model based on a conventional linear-quadratic (LQ) model and the photon equivalent dose, without considering the dose dependency of the relative biological effectiveness (RBE), to fully comply with the carbon passive dose distribution using a ridge filter. We extended a passive ridge-filter design method, in which carbon and helium LQ parameters are applied to carbon and fragment isotopes, respectively, to carbon scanning treatment. We then obtained radiation quality data, such as the linear energy transfer (LET) and LQ parameters, by Monte Carlo simulation. The physical dose was verified to agree with measurements to within ±2% for various patterns of volume irradiation. Furthermore, the RBE in the middle of a spread-out Bragg peak (SOBP) reproduced that from passive dose distribution results to within ±1.5%. The developed carbon beam modeling and dose calculation program was successfully applied in clinical use at Osaka HIMAK.
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