ArticlePaediatric anaesthesia2021
Associations of perioperative characteristics with motor function in preschool children born with esophageal atresia.
Article in Paediatric anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
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Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.
- Anesthetic Exposure During Childhood and Neurodevelopmental Outcomes: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Long-term neurodevelopment in children born with esophageal atresia: a systematic review.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021Pooled it
- Complex trajectories are associated with neurological impairment in infants with congenital gastrointestinal malformations aged two.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Associations of perioperative characteristics with motor function in preschool children born with esophageal atresia.Paediatric anaesthesia · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren born with esophageal atresia experience long-term neurodevelopmental deficits, with unknown origin.
aimsTo find associations between perioperative variables during primary esophageal atresia repair and motor function at age 5 years.
methodsThis ambidirectional cohort study included children born with esophageal atresia who consecutively had been operated on in the Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, from January 2007 through June 2013. The perioperative data of this cohort were collected retrospectively; the motor function data prospectively.
resultsAfter exclusion of patients with syndromal congenital diseases (n = 8) and lost to follow-up (n = 10), the data of 53 children were included. The mean (SD) total motor function impairment z-score at 5 years of age was -0.66 (0.99), significantly below normal (p < .001). In multivariable linear regression analysis, number of postoperative days endotracheal intubation (B = -0.211, 95% CI: -0.389 to -0.033, p = .021) was negatively associated with motor outcome, whereas high blood pressure (B = 0.022, 95% CI 0.001 to 0.042, p = .038) was positively associated. Preoperative nasal oxygen supplementation versus room air (B = 0.706, 95% CI: 0.132 to 1.280, p = .016) was positively associated with motor outcome, which we cannot explain.
conclusionsMotor function in 5-year-old esophageal atresia patients was impaired and negatively associated with the number of postoperative days of endotracheal intubation and positively associated with high blood pressure. Prospective studies with critical perioperative monitoring and monitoring during stay at the intensive care unit are recommended.
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