Evidence map›Paper›PMID 33998023›Full record

ArticleThe EMBO journal2021

Keep the fate: how chromatin regulators safeguard embryonic stem cell identity.

Adrian Janiszewski, Grigorios Georgolopoulos, Martina Balli, Paraskevi Athanasouli, Frederic Lluis, Vincent Pasque

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Adrian JaniszewskiDepartment of Development and Regeneration, KU Leuven-University of Leuven, Leuven, Belgium.ORCID 0000-0002-4156-5791
Grigorios GeorgolopoulosDepartment of Development and Regeneration, KU Leuven-University of Leuven, Leuven, Belgium.ORCID 0000-0002-9906-4797
Martina BalliDepartment of Development and Regeneration, KU Leuven-University of Leuven, Leuven, Belgium.ORCID 0000-0003-0791-2021
Paraskevi AthanasouliDepartment of Development and Regeneration, KU Leuven-University of Leuven, Leuven, Belgium.
Frederic LluisDepartment of Development and Regeneration, KU Leuven-University of Leuven, Leuven, Belgium.
Vincent PasqueDepartment of Development and Regeneration, KU Leuven-University of Leuven, Leuven, Belgium.ORCID 0000-0002-5129-0146
IMEC · BEKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Segregation of cells that form the embryo from those that produce the surrounding extra-embryonic tissues is critical for early mammalian development, but the regulatory layers governing these first cell fate decisions remain poorly understood. Recent work in The EMBO Journal identifies two chromatin regulators, Hdac3 and Dax1, that synergistically restrict the developmental potential of mouse embryonic stem cells and act as a lineage barrier to primitive endoderm formation.

Indexed as

BlastocystChromatinAnimalsCell DifferentiationCell LineageEmbryo, MammalianEmbryonic Stem CellsEndodermMiceChromatin

Identifiers

PMID33998023
PMCPMC8204858
OpenAlexW3160766487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.