Evidence map›Paper›PMID 33997781›Full record

ArticleBrain communications2021

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in

Jessika C Bridi, Erika Bereczki, Saffron K Smith, Gonçalo M Poças, Benjamin Kottler, Pedro M Domingos, Christopher J Elliott, Dag Aarsland, Frank Hirth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 5 countries.

Jessika C BridiDepartment of Basic & Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London SE5 9RX, UK.ORCID https://orcid.org/0000-0002-7692-9866
Erika BereczkiDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Novum, Stockholm 171 77, Sweden.ORCID https://orcid.org/0000-0002-0373-7417
Saffron K SmithDepartment of Biology and York Biomedical Research Institute, University of York, York YO1 5DD, UK.ORCID https://orcid.org/0000-0003-0353-4836
Gonçalo M PoçasInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), Oeiras, Lisbon 2780-157, Portugal.
Benjamin KottlerDepartment of Basic & Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London SE5 9RX, UK.ORCID https://orcid.org/0000-0002-4551-5791
Pedro M DomingosInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), Oeiras, Lisbon 2780-157, Portugal.
Christopher J ElliottDepartment of Biology and York Biomedical Research Institute, University of York, York YO1 5DD, UK.
Dag AarslandDepartment of Old Age Psychiatry, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.
Frank HirthDepartment of Basic & Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London SE5 9RX, UK.ORCID https://orcid.org/0000-0001-8581-9450
King's College London · GBUniversity of York · GBKarolinska Institutet · SEMonash University · AUUniversidade Nova de Lisboa · PT

Funding

Motor Neurone Disease Association HIRTH/OCT13/868-792Motor Neurone Disease Association HIRTH/OCT16/890-792Parkinson's UK H-1201
6 · The paper itself

Abstract

Alpha-synuclein (α-syn) mislocalization and accumulation in intracellular inclusions is the major pathological hallmark of degenerative synucleinopathies, including Parkinson's disease, Parkinson's disease with dementia and dementia with Lewy bodies. Typical symptoms are behavioural abnormalities including motor deficits that mark disease progression, while non-motor symptoms and synaptic deficits are already apparent during the early stages of disease. Synucleinopathies have therefore been considered synaptopathies that exhibit synaptic dysfunction prior to neurodegeneration. However, the mechanisms and events underlying synaptopathy are largely unknown. Here we investigated the cascade of pathological events underlying α-syn accumulation and toxicity in a

Indexed as

active zoneneurodegenerationParkinson’s diseasesynaptopathyα-synuclein

Identifiers

PMID33997781
PMCPMC8111063
OpenAlexW3137635480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.