Evidence map›Paper›PMID 33997732›Full record

ArticleEClinicalMedicine2021

Association of maternal lipid profile and gestational diabetes mellitus: A systematic review and meta-analysis of 292 studies and 97,880 women.

Jiamiao Hu, Clare L Gillies, Shaoling Lin, Zoe A Stewart, Sarah E Melford, Keith R Abrams, Philip N Baker, Kamlesh Khunti, Bee K Tan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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  7. Ferroptosis-Mediated Placental Dysfunction in the Pathophysiology of Gestational Diabetes Mellitus.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jiamiao HuCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China.
Clare L GilliesDiabetes Research Centre, Leicester General Hospital, Leicester LE5 4PW, United Kingdom.
Shaoling LinCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China.
Zoe A StewartDepartment of Cardiovascular Sciences and Diabetes Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom.
Sarah E MelfordDepartment of Cardiovascular Sciences and Diabetes Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom.
Keith R AbramsHealth Sciences, University of Leicester, Leicester LE1 7RH, United Kingdom.
Philip N BakerDepartment of Cardiovascular Sciences and Diabetes Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom.
Kamlesh KhuntiDiabetes Research Centre, Leicester General Hospital, Leicester LE5 4PW, United Kingdom.
Bee K TanDepartment of Cardiovascular Sciences and Diabetes Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom.
University of Leicester · GBLeicester General Hospital · GBFujian Agriculture and Forestry University · CN

Funding

Medical Research Council MR/P013538/1Medical Research Council MR/P013538/2Medical Research Council MR/R020981/1Medical Research Council MR/R020981/2
6 · The paper itself

Abstract

backgroundGestational Diabetes Mellitus (GDM) is the most prevalent metabolic disorder during pregnancy, however, the association between dyslipidaemia and GDM remains unclear.

methodsWe searched Medline, Scopus, Web of Science, Cochrane, Maternity and Infant Care database (MIDIRS) and ClinicalTrials.gov up to February 2021 for relevant studies which reported on the circulating lipid profile during pregnancy, in women with and without GDM. Publications describing original data with at least one raw lipid [triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), or very low-density lipoprotein cholesterol (VLDL-C)] measurement were retained. Data extraction was performed using a piloted data extraction form. The protocol was registered with PROSPERO (CRD42019139696).

findingsA total of 292 studies, comprising of 97,880 pregnant women (28232 GDM and 69,648 controls) were included. Using random-effects meta-analysis models to pool study estimates, women with GDM had significantly higher (by 20%) TG levels, with a pooled weighted mean difference between GDM and non-GDM pregnancies of 0.388 mM (0.336, 0.439,

interpretationElevated lipids, particularly, TG, are associated with GDM.

Indexed as

Gestational diabetes mellitusLipidsOral glucose tolerance testTriglycerideVery low-density lipoprotein cholesterol

Identifiers

PMID33997732
PMCPMC8102708
OpenAlexW3156331861

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.