ArticleEClinicalMedicine2021
Association between cardiovascular risk factors and colorectal cancer: A systematic review and meta-analysis of prospective cohort studies.
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- The effect of excess body weight on short-term outcomes following minimally invasive rectal cancer surgery: a systematic review and meta-analysis.Techniques in coloproctology · 2026Pooled it
- Pooled it
- Is the association of overweight and obesity with colorectal cancer underestimated? An umbrella review of systematic reviews and meta-analyses.European journal of epidemiology · 2023Pooled it
- Platelet P2Y12 inhibitor use and risk of colorectal cancer incidence and colorectal cancer-related mortality: a Swedish registry-based cohort study.BMC gastroenterology · 2026Article
- Statin Initiation and Mortality After Colorectal Cancer Treatment.JAMA network open · 2026Article
- Retinal Vascular Features and Risk of Colorectal Cancer Incidence and Mortality: A Population-Based Cohort Study.Ophthalmology and therapy · 2026Article
- Leveraging Text Messaging and Behavior Theory to Improve Colorectal Cancer Screening in Federally Qualified Health Centers: Cohort Study.Journal of medical Internet research · 2026Article
- Impact of sedation on adenoma and polyp detection rates and cecal intubation in elderly patients undergoing screening colonoscopy.World journal of gastrointestinal pharmacology and therapeutics · 2026Article
- Hypertension as a Predictor of Ovarian Cancer Risk: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Mortality trends in heart failure and colon cancer: Insights into gender, ethnic, and regional disparities in the United States (1999-2020).American heart journal plus : cardiology research and practice · 2026Article
- Trends in ischemic heart disease mortality among older adults with co-existing colorectal cancer in the US (1999-2023): a 25-Year retrospective study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Article
- Role of COUP‑TFII in cardiovascular diseases and colorectal cancer: Insights into the molecular mechanisms and clinical relevance (Review).Molecular medicine reports · 2025Review
- Cardiovascular Risk, Health Metrics, and Cancer Prediction: A Scoping Review.JACC. CardioOncology · 2025Article
- Central obesity may account for most of the colorectal cancer risk linked to obesity: evidence from the UK Biobank prospective cohort.International journal of obesity (2005) · 2025Article
- Increased risk of colorectal cancer in young males with higher cardiovascular risk: A nationwide population-based cohort study.World journal of gastrointestinal oncology · 2025Article
- Overcoming underestimation of the share of colorectal cancer cases attributable to excess weight: a population-based study.Obesity (Silver Spring, Md.) · 2025Article
- Obesity-Associated Colorectal Cancer.International journal of molecular sciences · 2024Review
- Association of Life's Essential 8 with all-cause mortality and risk of cancer: a prospective cohort study.BMC public health · 2024Article
- Prognostic relevance of ventricular arrhythmias in surgical patients with gastrointestinal tumors.World journal of gastrointestinal oncology · 2024Article
- Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging data have suggested colorectal cancer (CRC) often coexists with cardiovascular diseases, but whether cardiovascular risk factors play a role in CRC remains unclear. We performed a systematic review and meta-analysis to better illustrate the associations between cardiovascular risk factors and CRC.
methodsWe searched EMBASE, MEDLINE and Web of Science databases from inception up to June 14, 2020. Prospective cohort studies were included if they evaluated the association between at least one of cardiovascular risk factors and CRC incidence, containing sufficient data to obtain relative risk (RR) and 95% confidence interval (CI). We performed separate meta-analyses for each cardiovascular risk factor using random-effect model. PROSPERO registration number
findingsData from 84 studies, reporting 52, 348, 827 individuals and 384, 973 incident cases were included in the analysis. Overall, the risk of CRC was 1.31(95% CI, 1.21-1.42) for obesity, 1.14 (95% CI, 1.09-1.20) for per 5 kg/m
interpretationUnfavorable cardiovascular risk factors are associated with increased risk of CRC, which may provide novel insight into the screening strategies of CRC in patient with these risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.