Evidence map›Paper›PMID 33997707›Full record

ArticleiScience2021

Astrocytes promote ethanol-induced enhancement of intracellular Ca

Hyun-Bum Kim, Jacqueline Morris, Kevin Miyashiro, Tõnis Lehto, Ülo Langel, James Eberwine, Jai-Yoon Sul

Abstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Ultrastructural Characteristics of the Juvenile Chum Salmon (International journal of molecular sciences · 2025
    Article
  2. Article
  3. Article
  4. Astrocytic transcriptional and epigenetic mechanisms of drug addiction.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  5. Article
  6. Acute activation of hemichannels by ethanol leads to CaFrontiers in cell and developmental biology · 2024
    Article
  7. Astrocyte-specific CaBiochemistry and cell biology = Biochimie et biologie cellulaire · 2023
    Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hyun-Bum KimDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jacqueline MorrisDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kevin MiyashiroDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tõnis LehtoDepartment of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Svante Arrhenius väg 16B, 10691, Stockholm, Sweden.
Ülo LangelDepartment of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Svante Arrhenius väg 16B, 10691, Stockholm, Sweden.
James EberwineDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jai-Yoon SulDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Funding

Nuclear pre-mRNA analysis of single cells in brain sliceR33MH106637 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SUL, JAI-YOON · 2014 to 2016
$1.2M
NIMH NIH HHS R33 MH106637
6 · The paper itself

Abstract

Ethanol (EtOH) abuse induces significant mortality and morbidity worldwide because of detrimental effects on brain function. Defining the contribution of astrocytes to this malfunction is imperative to understanding the overall EtOH effects due to their role in homeostasis and EtOH-seeking behaviors. Using a highly controllable

Indexed as

BiochemistryCell BiologyNeurosciencePharmacology

Identifiers

PMID33997707
PMCPMC8105650

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.