Evidence map›Paper›PMID 33997706›Full record

ArticleiScience2021

MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast transdifferentiation.

Lavinia Bisceglie, Ann-Katrin Hopp, Kapila Gunasekera, Roni H Wright, François Le Dily, Enrique Vidal, Alessandra Dall'Agnese, Luca Caputo, Chiara Nicoletti, Pier Lorenzo Puri and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Lavinia BisceglieDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Ann-Katrin HoppDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Kapila GunasekeraDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Roni H WrightCentre de Regulació Genomica (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain.
François Le DilyCentre de Regulació Genomica (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain.
Enrique VidalCentre de Regulació Genomica (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain.
Alessandra Dall'AgneseSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Luca CaputoSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Chiara NicolettiSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Pier Lorenzo PuriSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Miguel BeatoCentre de Regulació Genomica (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain.
Michael O HottigerDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Sanford Burnham Prebys Medical Discovery Institute · USUniversity of Zurich · CHCentre for Genomic Regulation · ESUniversitat Internacional de Catalunya · ESUniversitat Pompeu Fabra · ES

Funding

MYOD Regulation of 3D Chromatin StructureR01GM134712 · NIGMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI PURI, PIER LORENZO · 2019 to 2022
$1.6M
NIGMS NIH HHS R01 GM134712
6 · The paper itself

Abstract

While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation of fibroblasts to myoblasts promotes the expression of the ADP-ribosyltransferase

Indexed as

Biological SciencesCell BiologyDevelopmental BiologyMolecular Biology

Identifiers

PMID33997706
PMCPMC8102911
OpenAlexW3154736366

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.