Evidence map›Paper›PMID 33997700›Full record

ArticleiScience2021

Structural studies of the shortest extended synaptotagmin with only two C2 domains from

Emma Stepinac, Nicolas Landrein, Daria Skwarzyńska, Patrycja Wójcik, Johannes Lesigang, Iva Lučić, Cynthia Y He, Mélanie Bonhivers, Derrick R Robinson, Gang Dong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. The endoplasmic reticulum of trypanosomatids: An unrevealed road for chemotherapy.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Emma StepinacMax Perutz Labs, Vienna Biocenter, Center for Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria.
Nicolas LandreinUniversity of Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité, UMR 5234, 33000 Bordeaux, France.
Daria SkwarzyńskaMax Perutz Labs, Vienna Biocenter, Center for Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria.
Patrycja WójcikMax Perutz Labs, Vienna Biocenter, Center for Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria.
Johannes LesigangMax Perutz Labs, Vienna Biocenter, Center for Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria.
Iva LučićMax Perutz Labs, Vienna Biocenter, Center for Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria.
Cynthia Y HeDepartment of Biological Sciences, Center for BioImaging Sciences, National University of Singapore, Singapore, Singapore.
Mélanie BonhiversUniversity of Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité, UMR 5234, 33000 Bordeaux, France.
Derrick R RobinsonUniversity of Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité, UMR 5234, 33000 Bordeaux, France.
Gang DongMax Perutz Labs, Vienna Biocenter, Center for Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria.
Max Perutz Labs · ATCentre National de la Recherche Scientifique · FRSilesian University of Technology · PLNational University of Singapore · SG

Funding

Austrian Science Fund FWF I 4960Austrian Science Fund FWF P 28231
6 · The paper itself

Abstract

Extended synaptotagmins (E-Syts) localize at membrane contact sites between the endoplasmic reticulum (ER) and the plasma membrane to mediate inter-membrane lipid transfer and control plasma membrane lipid homeostasis. All known E-Syts contain an N-terminal transmembrane (TM) hairpin, a central synaptotagmin-like mitochondrial lipid-binding protein (SMP) domain, and three or five C2 domains at their C termini. Here we report an uncharacterized E-Syt from the protist parasite

Indexed as

BiochemistryBiochemistry ApplicationsMedical Biochemistry

Identifiers

PMID33997700
PMCPMC8093936
OpenAlexW3154219002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.