Evidence map›Paper›PMID 33997693›Full record

ArticleiScience2021

Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1.

Jae Hun Shin, Jaekwang Jeong, Jungmin Choi, Jaechul Lim, Ravi K Dinesh, Jonathan Braverman, Jun Young Hong, Stephen E Maher, Maria C Amezcua Vesely, WonJu Kim and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  8. TCF7L1 RegulatesGenes · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Jae Hun ShinDepartment of Immunobiology, Yale University School of Medicine, TAC 641D, PO Box 208011, 300 Cedar Street, New Haven, CT 06520-8011, USA.
Jaekwang JeongInternal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Jungmin ChoiDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
Jaechul LimDepartment of Immunobiology, Yale University School of Medicine, TAC 641D, PO Box 208011, 300 Cedar Street, New Haven, CT 06520-8011, USA.
Ravi K DineshDepartment of Immunobiology, Yale University School of Medicine, TAC 641D, PO Box 208011, 300 Cedar Street, New Haven, CT 06520-8011, USA.
Jonathan BravermanThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jun Young HongDepartment of Immunobiology, Yale University School of Medicine, TAC 641D, PO Box 208011, 300 Cedar Street, New Haven, CT 06520-8011, USA.
Stephen E MaherDepartment of Immunobiology, Yale University School of Medicine, TAC 641D, PO Box 208011, 300 Cedar Street, New Haven, CT 06520-8011, USA.
Maria C Amezcua VeselyDepartment of Immunobiology, Yale University School of Medicine, TAC 641D, PO Box 208011, 300 Cedar Street, New Haven, CT 06520-8011, USA.
WonJu KimDepartment of Life Science, College of Natural Science, Hanyang University, Seoul 04763, Republic of Korea.
Ja-Hyun KooDepartment of Life Science, College of Natural Science, Hanyang University, Seoul 04763, Republic of Korea.
Wenwen TangVascular Biology and Therapeutic Program and Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Dianqing WuVascular Biology and Therapeutic Program and Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Holly N BlackburnDepartment of Immunobiology, Yale University School of Medicine, TAC 641D, PO Box 208011, 300 Cedar Street, New Haven, CT 06520-8011, USA.
Rosa M XicolaDepartment of Medicine and Cancer Center, Yale University, New Haven, CT 06520, USA.
Xavier LlorDepartment of Medicine and Cancer Center, Yale University, New Haven, CT 06520, USA.
Omer YilmazThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Je-Min ChoiDepartment of Life Science, College of Natural Science, Hanyang University, Seoul 04763, Republic of Korea.
Alfred L M BothwellDepartment of Immunobiology, Yale University School of Medicine, TAC 641D, PO Box 208011, 300 Cedar Street, New Haven, CT 06520-8011, USA.
Yale University · USHanyang University · KRKorea University · KRYale Cancer Center · USMassachusetts General Hospital · USMassachusetts Institute of Technology · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
DKK2 regulates NK activation and tumor immunityR01CA214703 · NCI · YALE UNIVERSITY · PI WU, DIANQING · 2018 to 2022
$2.5M
Regulatory T Cell Control of Intestinal TumorigenesisR01CA168670 · NCI · YALE UNIVERSITY · PI BOTHWELL, ALFRED LM · 2014 to 2018
$2.1M
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA168670NCI NIH HHS R01 CA214703
6 · The paper itself

Abstract

Enhanced stemness in colorectal cancer has been reported and it contributes to aggressive progression, but the underlying mechanisms remain unclear. Here we report a Wnt ligand, Dickkopf-2 (DKK2) is essential for developing colorectal cancer stemness. Genetic depletion of

Indexed as

CancerCell BiologyStem Cells Research

Identifiers

PMID33997693
PMCPMC8099562
OpenAlexW3154713338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.