ArticleiScience2021
A single-cell atlas of human teeth.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed.
- Spatial Transcriptomics-Inspired Targeted Hydrogel for Dental Pulp Therapy via Strengthen Macrophage Communication.Advanced healthcare materials · 2026Article
- Single-Cell Analysis Reveals the Soft Tissue Structure Heterogeneity Aggravates Peri-Implantitis Through MDK Signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- In Vitro Single-Cell Transcriptomic Profiling of Cultured Stem Cells From Apical Papilla and Dental Pulp Stem Cells: Unveiling Cellular Heterogeneity.International dental journal · 2026Article
- Embryonic and postnatal macrophages are necessary for proper tooth development and homeostasis.Nature communications · 2026Article
- Automatic extraction of mesenchymal stromal cells from single-cell RNA-sequencing data of human dental pulp.BioData mining · 2026Article
- Human CD24Nature communications · 2026Article
- Th17/IL-17A Drives Alveolar Bone Loss via the JAK/STAT3-RANKL Axis in the Periodontal Ligament.Oral diseases · 2026Article
- Wnt-dependent ontogeny of acellular cementum-forming cementoblasts on the tooth root surface.Nature communications · 2026Article
- An integrated single-cell and spatial proteotranscriptomics atlas of fibroblast-driven immunoregulation within the human adult oral cavity.Cell press blue · 2026Article
- Research progress in heterogeneity of dental mesenchymal stem cells.International journal of oral science · 2026Review
- A microfluidic model of human dental pulp angiogenesis for preclinical drug and biomaterial testing.Materials today. Bio · 2026Article
- Identification of Smmhc-expressing mesenchymal cells in orofacial bone at single-cell resolution.Bone research · 2026Article
- Identification of GLDNInternational journal of oral science · 2026Article
- Enamel decussation pattern originates from directional sliding of ameloblasts.International journal of oral science · 2026Article
- Characterising the Periodontal Granulation Tissue Using scRNAseq.Journal of clinical periodontology · 2026Article
- Dissecting Heterogeneity Reveals Functional Subpopulation of Stem Cells From Human Exfoliated Deciduous Teeth.International dental journal · 2026Article
- Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Single-Cell Transcriptomic Atlas of Epithelial Cell Heterogeneity During the Crown-to-Root Transition in the Mouse Molar.International journal of molecular sciences · 2026Article
- Long-Term Biobanked Dental Pulp Stem Cells Retain Angiogenic Potential for Vascularised Tissue Engineering-Laboratory Investigation.International endodontic journal · 2026Article
- The light at the other end of the tunnel: heeding two decades of regeneration research to reclaim natural tooth preservation.Frontiers in bioengineering and biotechnology · 2026Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Teeth exert fundamental functions related to mastication and speech. Despite their great biomedical importance, an overall picture of their cellular and molecular composition is still missing. In this study, we have mapped the transcriptional landscape of the various cell populations that compose human teeth at single-cell resolution, and we analyzed in deeper detail their stem cell populations and their microenvironment. Our study identified great cellular heterogeneity in the dental pulp and the periodontium. Unexpectedly, we found that the molecular signatures of the stem cell populations were very similar, while their respective microenvironments strongly diverged. Our findings suggest that the microenvironmental specificity is a potential source for functional differences between highly similar stem cells located in the various tooth compartments and open new perspectives toward cell-based dental therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.