Evidence map›Paper›PMID 33997642›Full record

ReviewMayo Clinic proceedings. Innovations, quality & outcomes2021

Financial Conflicts of Interest in Clinical Practice Guidelines: A Systematic Review.

Sahar Tabatabavakili, Rishad Khan, Michael A Scaffidi, Nikko Gimpaya, David Lightfoot, Samir C Grover

Abstract readReview
In one paragraph

Review in Mayo Clinic proceedings. Innovations, quality & outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Doctors' Conflict-of-Interest; What it Looks Like and What to do About it.International journal of social determinants of health and health services · 2026
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  15. How to recognize a trustworthy clinical practice guideline.Journal of anesthesia, analgesia and critical care · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sahar TabatabavakiliDepartment of Medicine, University of Toronto, Ontario, Canada.
Rishad KhanDepartment of Medicine, University of Toronto, Ontario, Canada.
Michael A ScaffidiDivision of Gastroenterology, St. Michael's Hospital, Toronto, Ontario, Canada.
Nikko GimpayaDivision of Gastroenterology, St. Michael's Hospital, Toronto, Ontario, Canada.
David LightfootHealth Science Library, Unity Health Toronto, St. Michael's Hospital, Toronto, Ontario, Canada.
Samir C GroverDepartment of Medicine, University of Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo systematically evaluate the prevalence of disclosed and undisclosed financial conflicts of interest (FCOI) among clinical practice guidelines (CPGs).

methodsIn this systematic review, we ascertained the prevalence and types of FCOI for CPGs from January 1, 1980, to March 3, 2019. The primary outcome was the prevalence of FCOI among authors of CPGs. FCOI disclosures were compared between medical subspecialties and societies producing CPGs.

resultsAmong the 37 studies including 14,764 total guideline authors, 45% had at least one FCOI. The prevalence of FCOI per study ranged from 6% to 100%. More authors had FCOI involving general payments (39%) compared with research payments (29%). Oncology, neurology, and gastroenterology had the highest prevalence of FCOI compared with other medical specialties. Among the 8 studies that included the monetary values in US dollars of FCOI, average payments per author ranged from $578 to $242,300. Among the 10 studies that included data on undisclosed FCOI, 32% of authors had undisclosed industry payments.

conclusionThere are numerous FCOI among authors of CPGs, many of which are undisclosed

Indexed as

CMS-OP, Centers for Medicare & Medicaid Services Open PaymentsCPG, clinical practice guidelineFCOI, financial conflicts of interest

Identifiers

PMID33997642
PMCPMC8105509

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.