ArticleMayo Clinic proceedings. Innovations, quality & outcomes2021
Clinical and Economic Burden of Stroke Among Young, Midlife, and Older Adults in the United States, 2002-2017.
Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Literature Review on the Burden of Disease for Patients With Moderate to Severe Acute Ischemic Stroke.Medicine · 2025Pooled it
- Indoor Radon Concentrations and Hematologic Traits in the Women's Health Initiative.Epidemiology (Cambridge, Mass.) · 2026Article
- Network Analysis-Driven Machine Learning Model for Identifying High-Cost Stroke Inpatients Using Hospital Discharge Data: Retrospective Study.JMIR medical informatics · 2026Article
- Article
- Cinchonidine, a Natural Quinoline Alkaloid, Attenuates Ischemic Neurovascular Injury Through Blood-Brain Barrier Preservation.Biomedicines · 2026Article
- Long-term exposure to wildfire smoke particulate matter and incident stroke: a US nationwide study.European heart journal · 2026Article
- ANGWC Nomogram for Predicting Poor 3-month Outcome after Intravenous Thrombolysis in Young and Middle-Aged Patients with First-Ever Stroke.Thrombosis and haemostasis · 2026Article
- Health-Economic Implications of Post-Stroke Dysphagia: A Contemporary Medicare Claims Analysis.Neurology and therapy · 2026Article
- Ischaemic stroke in young adults: an overview of the classification, risk factors, aetiologies and outcomes.Singapore medical journal · 2026Review
- Comparisons of Functional, Physical, and Mental Health Outcomes Among Young and Old Stroke Survivors.Geriatrics (Basel, Switzerland) · 2026Article
- The Role of TREM2 After Stroke: From Mechanisms to Therapeutic Potential.Molecular neurobiology · 2025Review
- Effect of Time from Puncture to Recanalization on Poststroke Disposition and Associated Costs.Stroke (Hoboken, N.J.) · 2025Article
- Intracerebral hemorrhage hospitalizations and outcomes: comparisons between institutional and national data.Internal and emergency medicine · 2025Article
- Navigating the life stage after stroke: From Life 2.0 to stroke prevention models of care - A qualitative exploration of younger and middle-aged adult stroke patients' experiences and recommendations.Qualitative research in medicine & healthcare · 2025Article
- Protocol for a randomized controlled trial evaluating the artificial intelligence health education accurately linking system in patients with mild-to-moderate stroke.Frontiers in neurology · 2025Article
- Experiences of Young and Middle-Aged Stroke Patients with Hemiplegia Who Actively Participate in Rehabilitation Exercises and Their Perceptions of Well-Being: A Descriptive Qualitative Study.Risk management and healthcare policy · 2025Article
- Comorbidity and cost burden among ischemic stroke inpatients aged 60 years and older in middle-high-income region in China: a multicenter cross-sectional study.Frontiers in public health · 2025Article
- Global burden of stroke in adolescents and young adults (aged 15-39 years) from 1990 to 2019: a comprehensive trend analysis based on the global burden of disease study 2019.BMC public health · 2024Article
- Healthcare professionals' experiences of delivering a stroke Early Supported Discharge service - An example from Ireland.Clinical rehabilitation · 2024Article
- Experience of financial toxicity and coping strategies in young and middle-aged patients with stroke: a qualitative study.BMC health services research · 2024Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess trends of stroke hospitalization rates, inpatient mortality, and health care resource use in young (aged ≤44 years), midlife (aged 45-64 years), and older (aged ≥65 years) adults. PATIENTS AND
methodsWe studied the National Inpatient Sample database (January 1, 2002 to December 31, 2017) to analyze stroke-related hospitalizations. We identified data using the
resultsOf 11,381,390 strokes, 79% (n=9,009,007) were ischemic and 21% (n=2,372,383) were hemorrhagic. Chronic diseases were more frequent in older adults; smoking, alcoholism, and migraine were more prevalent in midlife adults; and coagulopathy and intravenous drug abuse were more common in young patients with stroke. The hospitalization rates of stroke per 10,000 increased overall (31.6 to 33.3) in young and midlife adults while decreasing in older adults. Although mortality decreased overall and in all age groups, the decline was slower in young and midlife adults than older adults. The mean length of stay significantly decreased in midlife and older adults and increased in young adults. The inflation-adjusted mean cost of stay increased consistently, with an average annual growth rate of 2.44% in young, 1.72% in midlife, and 1.45% in older adults owing to the higher use of health care resources. These trends were consistent in both ischemic and hemorrhagic stroke.
conclusionStroke-related hospitalization and health care expenditure are increasing in the United States, particularly among young and midlife adults. A higher cost of stay counterbalances the benefits of reducing stroke and mortality in older patients.
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