Evidence map›Paper›PMID 33997638›Full record

ArticleMayo Clinic proceedings. Innovations, quality & outcomes2021

Elevated Serum Lactate in Patients With Lymphoma: It Is Not Always Infection.

Gordon J Ruan, Sangeetha Gandhi, Jithma P Abeykoon, Susan Schram, Thomas M Habermann, Benjamin J Sandefur, Thomas E Witzig

Open access · goldAbstract read
In one paragraph

Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. How lactate affects immune strategies in lymphoma.Frontiers in molecular biosciences · 2024
    Review
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gordon J RuanDepartment of Internal Medicine, Mayo Clinic, Rochester, MN.
Sangeetha GandhiDivision of Hematology, Mayo Clinic, Rochester, MN.
Jithma P AbeykoonDivision of Hematology, Mayo Clinic, Rochester, MN.
Susan SchramDivision of Hematology, Mayo Clinic, Rochester, MN.
Thomas M HabermannDivision of Hematology, Mayo Clinic, Rochester, MN.
Benjamin J SandefurDepartment of Emergency Medicine, Mayo Clinic, Rochester, MN.
Thomas E WitzigDivision of Hematology, Mayo Clinic, Rochester, MN.
Mayo Clinic in Arizona · US

Funding

The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7M
NCI NIH HHS P50 CA097274
6 · The paper itself

Abstract

objectiveTo distinguish between sepsis only vs progressive lymphoma in patients with a history of lymphoma who present to the hospital with lactic acidosis. PATIENTS AND

methodsWe identified patients with non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma from January 2014 to December 2015. Patients were categorized into 2 groups: sepsis only or progressive lymphoma. Two-sided Wilcoxon rank sum test and χ

resultsA total of 51 patients were identified; 33 (65%) patients were categorized into the sepsis only group, and 18 (35%), into the progressive lymphoma group. Values for serum lactate dehydrogenase (LDH) drawn during hospitalization were statistically different between the sepsis only and progressive lymphoma groups (median, 262 vs 665 U/L;

conclusionSerum LDH levels used in conjunction with serial serum lactate values may be reliable markers to differentiate patients with progressive lymphomatous disease from patients with lymphoma with sepsis only. The LDH levels should be obtained in all patients with lymphoma who present to the hospital with lactic acidosis.

Indexed as

ATP, adenosine triphosphateCoA, coenzyme ACT, computed tomographyDLBCL, diffuse large B-cell lymphomaGLUT, facilitative glucose transporterHR, hazard ratioIQR, interquartile rangeLDH, lactate dehydrogenaseMCT, monocarboxylate transporterNADH, nicotinamide adenine dinucleotide and hydrogenNAD, nicotinamide adenine dinucleotideNHL, non-Hodgkin lymphomaO2, oxygenOS, overall survivalTCA, tricarboxylic acidULN, upper limit of normal

Identifiers

PMID33997638
PMCPMC8105511
OpenAlexW3153976540

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.