Evidence map›Paper›PMID 33997627›Full record

ArticleMayo Clinic proceedings. Innovations, quality & outcomes2021

Cardiovascular and Renal Outcomes Associated With Hyperkalemia in Chronic Kidney Disease: A Hospital-Based Cohort Study.

Shun Kohsaka, Suguru Okami, Eiichiro Kanda, Naoki Kashihara, Toshitaka Yajima

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Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shun KohsakaDepartment of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Suguru OkamiCardiovascular, Renal, and Metabolism, Medical Affairs, AstraZeneca KK, Osaka, Japan.
Eiichiro KandaMedical Science, Kawasaki Medical School, Okayama, Japan.
Naoki KashiharaDepartment of Nephrology and Hypertension, Kawasaki Medical School, Okayama, Japan.
Toshitaka YajimaCardiovascular, Renal, and Metabolism, Medical Affairs, AstraZeneca KK, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the association between hyperkalemia and long-term cardiovascular and renal outcomes in patients with chronic kidney disease. PATIENTS AND

methodsAn observational retrospective cohort study was performed using a Japanese hospital claims registry, Medical Data Vision (April 1, 2008, to September 30, 2018). Of 1,208,894 patients with at least 1 potassium measurement, 167,465 patients with chronic kidney disease were selected based on

resultsOf 16,133 hyperkalemic patients and 11,898 normokalemic controls eligible for analyses, 5859 (36.3%) patients and 5859 (49.2%) controls were selected after propensity score matching. The mean follow-up period was 3.5 years. The 3-year eGFR change in patients and controls was -5.75 and -1.79 mL/min/1.73 m

conclusionHyperkalemia was associated with significant risks for mortality and adverse clinical outcomes, with more rapid decline of renal function. These findings underscore the significance of hyperkalemia as a predisposition to future adverse events in patients with chronic kidney disease.

Indexed as

ACEi, angiotensin-converting enzyme inhibitorARB, angiotensin receptor blockerCKD, chronic kidney diseaseDM, diabetes mellituseGFR, estimated glomerular filtration rateHDL, high-density lipoproteinHF, heart failureICD-10, International Classification of Diseases, Tenth RevisionLDL, low-density lipoproteinMDV, Medical Data VisionMRA, mineralocorticoid receptor antagonistPS, propensity scoreRAASi, renin-angiotensin-aldosterone system inhibitorRRT, renal replacement therapyS-K, serum potassium

Identifiers

PMID33997627
PMCPMC8105529

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.