ArticleBioactive materials2021
Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits.
Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Curative efficacy of surgical procedures for older patients with femoral neck fracture: a network meta-analysis and systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Prospective Pilot Clinical Study of High-Purity Magnesium Plates and Screws for Le Fort I Osteosynthesis.International dental journal · 2026Article
- Three-dimensional cell sheet model improvesBioactive materials · 2025Article
- Biomechanical analysis of biodegradable magnesium, zinc, and polylactide pins for fixation of radial head fractures.Journal of orthopaedic surgery and research · 2025Article
- The Recent Developments of Thermomechanical Processing for Biomedical Mg Alloys and Their Clinical Applications.Materials (Basel, Switzerland) · 2025Review
- Degradation behavior of porous magnesium alloy scaffold under the low-intensity pulsed ultrasound intervention and their effect on bone defects repair.Regenerative biomaterials · 2025Article
- Failure analysis and design improvement of retrieved plates from revision surgery.Journal of orthopaedic translation · 2024Article
- Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications.Bioactive materials · 2024Review
- Research status and prospects of biodegradable magnesium-based metal guided bone regeneration membranes.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024Review
- Degradation behavior of ZE21C magnesium alloy suture anchors and their effect on ligament-bone junction repair.Bioactive materials · 2023Article
- Nano artificial periosteum PLGA/MgO/Quercetin accelerates repair of bone defects through promoting osteogenic - angiogenic coupling effect via Wnt/ β-catenin pathway.Materials today. Bio · 2022Article
- Magnesium-Encapsulated Injectable Hydrogel and 3D-Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Potential bioactive coating system for high-performance absorbable magnesium bone implants.Bioactive materials · 2022Review
- Magnesium-Based Alloys Used in Orthopedic Surgery.Materials (Basel, Switzerland) · 2022Review
- Quality of reporting and adherence to the ARRIVE guidelines 2.0 for preclinical degradable metal research in animal models of bone defect and fracture: a systematic review.Regenerative biomaterials · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular congruity. Fracture fixation with biodegradable magnesium (Mg) pins enhanced fracture healing. We hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically, mechanically, and histologically. Transverse patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White Rabbits. The fracture was fixed with a pin made of stainless steel or pure Mg, and a figure-of-eight stainless steel band wire. Samples were harvested at week 8 or 12, and assessed with microCT, tensile testing, microindentation, and histology. Microarchitectural analysis showed that Mg group showed 12% higher in the ratio of bone volume to tissue volume at week 8, and 38.4% higher of bone volume at week 12. Tensile testing showed that the failure load and stiffness of Mg group were 66.9% and 104% higher than the control group at week 8, respectively. At week 12, Mg group was 60.8% higher in ultimate strength than the control group. Microindentation showed that, compared to the Control group, Mg group showed 49.9% higher Vickers hardness and 31% higher elastic modulus at week 8 and 12, respectively. At week 12, the new bone of Mg group remodelled to laminar bone, but those of the control group remained woven bone-like. Fixation of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.