Evidence map›Paper›PMID 33997357›Full record

ArticleSynthetic and systems biotechnology2021

Comparative metagenomic analysis of the vaginal microbiome in healthy women.

Fei Liu, Yingshun Zhou, Lisi Zhu, Zhiyi Wang, LiangKun Ma, Yuan He, Pengcheng Fu

Open access · goldAbstract read
In one paragraph

Article in Synthetic and systems biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Orally administratedFrontiers in immunology · 2023
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Analysis of metagenomic data.Nature reviews. Methods primers · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Dynamical alterations of brain function and gut microbiome in weight loss.Frontiers in cellular and infection microbiology · 2023
    Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Fei LiuCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Yingshun ZhouDepartment of Pathogenic Biology, Pathogenic Biology platform, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
Lisi ZhuLaboratory of Clinical Genetics, Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Zhiyi WangCAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
LiangKun MaPeking Union Medical College Hospital (Dongdan Campus), No. 1 Shuai Fu Yuan, Beijing, 100730, China.
Yuan HeNational Human Genetic Resources Center, National Research Institute for Health and Family Planning, Beijing, China.
Pengcheng FuMybiome (Beijing) Medical Consulting Co. LTD, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNChinese Academy of Sciences · CNNational Health and Family Planning Commission · CNSouthwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The composition of these vaginal microbiome has a significant impact on women's health. However, few studies have characterized the vaginal microbiome of healthy Chinese women using metagenomic sequencing. Here, we carried out a comparative metagenomic analysis to survey taxonomic, functional levels, and microbial communities' genome content in healthy women's vaginal microbiome. Overall, we observed a total of 111 species, including all dominant vaginal

Indexed as

CSTs, community state typesGenomeMetabolic pathwaysMetagenomeNMDS, nonmetric multidimensional scalingPCoA, Principal Coordinate AnalysisPERMANOVA, Permutational multivariate analysis of varianceStrainsTNF, tetranucleotide frequencyVaginal microbiome

Identifiers

PMID33997357
PMCPMC8085786
OpenAlexW3154805392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.