ArticleOsteoporosis and sarcopenia2021
Systematic review and meta-analysis of lean mass and mortality: Rationale and study description.
Article in Osteoporosis and sarcopenia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Cisplatin-Induced Skeletal Muscle Atrophy: Biomolecular Mechanisms and the Protective Role of Exercise-Induced Myokines.Biomolecules · 2025Review
- Body Composition and Its Outcomes and Management in Multiple Sclerosis: Narrative Review.Nutrients · 2025Review
- Article
- Muscle distribution in relation to all-cause and cause-specific mortality in young and middle-aged adults.Journal of translational medicine · 2023Article
- Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement.Obesity facts · 2022Article
- Nutritional Management in Bariatric Surgery Patients.International journal of environmental research and public health · 2021Review
- Summary of the special issue of the meta-analyses of lean mass with mortality in multiple perspectives.Osteoporosis and sarcopenia · 2021Review
- Different definition of sarcopenia and mortality in cancer: A meta-analysis.Osteoporosis and sarcopenia · 2021Article
- Sarcopenia and mortality in different clinical conditions: A meta-analysis.Osteoporosis and sarcopenia · 2021Article
- The effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis.Osteoporosis and sarcopenia · 2021Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMuscle mass is one of the key components in defining sarcopenia and is known to be important for locomotion and body homeostasis. Lean mass is commonly used as a surrogate of muscle mass and has been shown to be associated with increased mortality. However, the relationship of lean mass with mortality may be affected by different clinical conditions, modalities used, cut-off point to define low or normal lean mass, and even types of cancer among cancer patients. Thus, we aim to perform a comprehensive meta-analysis of lean mass with mortality by considering all these factors.
methodsSystematic search was done in PubMed, Cochrane Library and Embase for articles related to lean mass and mortality. Lean mass measured by dual X-ray absorptiometry, bioelectrical impedance analysis, and computerized tomography were included.
resultsThe number of relevant studies has increased continuously since 2002. A total of 188 studies with 98 468 people were included in the meta-analysis. The association of lean mass with mortality was most studied in cancer patients, followed by people with renal diseases, liver diseases, elderly, people with cardiovascular disease, lung diseases, and other diseases. The meta-analysis can be further conducted in subgroups based on measurement modalities, site of measurements, definition of low lean mass adopted, and types of cancer for studies conducted in cancer patients.
conclusionsThis series of meta-analysis provided insight and evidence on the relationship between lean mass and mortality in all directions, which may be useful for further study and guideline development.
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