ReviewTemperature (Austin, Tex.)2021
Kidney physiology and pathophysiology during heat stress and the modification by exercise, dehydration, heat acclimation and aging.
Review in Temperature (Austin, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.
- Pediatric kidney health outcomes in communities impacted by chronic kidney disease of unknown etiology (CKDu): a systematic review.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Hydrating with a higher-fructose sport drink does not worsen acute kidney injury risk during simulated work-related heat stress.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Trial
- Eight weeks of MitoQ supplementation does not alter kidney function or urinary kidney injury biomarkers in middle-aged and older adults.American journal of physiology. Renal physiology · 2026Trial
- Trial
- Beverage-Specific Modulation of Urinary Inflammatory Biomarkers After Endurance Running in Trained Males.Nutrients · 2025Trial
- Exploring the effects of outdoor physical work in the heat, with or without sodium bicarbonate supplementation, on markers of acute kidney injury.Physiological reports · 2025Trial
- Effect of pedestal fan use on serum stress biomarkers in older adults exposed to simulated daylong indoor overheating.Physiological reports · 2025Trial
- Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia after Running in the Heat.Medicine and science in sports and exercise · 2025Trial
- Acute exposure to carbon monoxide inhalation and/or hot water immersion transiently increases erythropoietin in females but not in males.Experimental physiology · 2024Trial
- Renal vascular control during normothermia and passive heat stress does not differ between healthy younger men and women.American journal of physiology. Renal physiology · 2024Trial
- Acute high-dose MitoQ does not increase urinary kidney injury markers in healthy adults: a randomized crossover trial.American journal of physiology. Renal physiology · 2024Trial
- Glomerular filtration rate reserve is reduced during mild passive heat stress in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- Water intake mediates cross-sectional associations between urinary kidney injury biomarkers and race in emerging adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Seasonality of acute kidney injury incidence in Japanese outpatients.Scientific reports · 2026Article
- Article
- Impact of heatwave exposure on chronic kidney disease risk among middle-aged and older adults: evidence from the China health and retirement longitudinal study.BMC nephrology · 2026Article
- Disparity in the regulation and prevention of water versus sodium imbalance in heat-stress nephropathy: a phylogenetic perspective.Clinical kidney journal · 2026Review
- Nuclear Magnetic Resonance-Based Urinary Metabolic Profiling for Assessing Heat Stress-Related Incident Kidney Injury in Health-Care Workers.GeoHealth · 2026Article
- Fluid balance, kidney function, and acute kidney injury risk in healthy men and women during simulated work-related heat stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers-Plasma Biochemistry.Animals : an open access journal from MDPI · 2026Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The kidneys' integrative responses to heat stress aid thermoregulation, cardiovascular control, and water and electrolyte regulation. Recent evidence suggests the kidneys are at increased risk of pathological events during heat stress, namely acute kidney injury (AKI), and that this risk is compounded by dehydration and exercise. This heat stress related AKI is believed to contribute to the epidemic of chronic kidney disease (CKD) occurring in occupational settings. It is estimated that AKI and CKD affect upwards of 45 million individuals in the global workforce. Water and electrolyte disturbances and AKI, both of which are representative of kidney-related pathology, are the two leading causes of hospitalizations during heat waves in older adults. Structural and physiological alterations in aging kidneys likely contribute to this increased risk. With this background, this comprehensive narrative review will provide the first aggregation of research into the integrative physiological response of the kidneys to heat stress. While the focus of this review is on the human kidneys, we will utilize both human and animal data to describe these responses to passive and exercise heat stress, and how they are altered with heat acclimation. Additionally, we will discuss recent studies that indicate an increased risk of AKI due to exercise in the heat. Lastly, we will introduce the emerging public health crisis of older adults during extreme heat events and how the aging kidneys may be more susceptible to injury during heat stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.