Evidence map›Paper›PMID 33996831›Full record

ArticleFrontiers in cell and developmental biology2021

Ultra-High Dose Rate FLASH Irradiation Induced Radio-Resistance of Normal Fibroblast Cells Can Be Enhanced by Hypoxia and Mitochondrial Dysfunction Resulting From Loss of Cytochrome C.

Jintao Han, Zhusong Mei, Chunyang Lu, Jing Qian, Yulan Liang, Xiaoyi Sun, Zhuo Pan, Defeng Kong, Shirui Xu, Zhipeng Liu and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Mechanisms of the FLASH effect: current insights and advances.Frontiers in cell and developmental biology · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. FLASH Radiotherapy: Expectations, Challenges, and Current Knowledge.International journal of molecular sciences · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 1 country.

Jintao HanState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Zhusong MeiState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Chunyang LuState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Jing QianTeaching and Research Section of Nuclear Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Yulan LiangState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Xiaoyi SunState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Zhuo PanState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Defeng KongState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Shirui XuState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Zhipeng LiuState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Ying GaoState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Guijun QiState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Yinren ShouState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Shiyou ChenState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Zhengxuan CaoState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Ye ZhaoTeaching and Research Section of Nuclear Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Chen LinState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Yanying ZhaoState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Yixing GengState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Jiaer ChenState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Xueqing YanState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Wenjun MaState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Gen YangState Key Laboratory of Nuclear Physics and Technology, School of Physics and CAPT, Peking University, Beijing, China.
Peking University · CNKey Laboratory of Nuclear Radiation and Nuclear Energy Technology · CNState Key Laboratory of Nuclear Physics and TechnologyAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultra-high dose rate FLASH irradiation (FLASH-IR) has got extensive attention since it may provide better protection on normal tissues while maintain tumor killing effect compared with conventional dose rate irradiation. The FLASH-IR induced protection effect on normal tissues is exhibited as radio-resistance of the irradiated normal cells, and is suggested to be related to oxygen depletion. However, the detailed cell death profile and pathways are still unclear. Presently normal mouse embryonic fibroblast cells were FLASH irradiated (∼10

Indexed as

cell deathcytochrome cFLASHhypoxiamitochondrianormoxiaradio-resistanceultra-high dose rate irradiation

Identifiers

PMID33996831
PMCPMC8121317
OpenAlexW3159171143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.