Evidence map›Paper›PMID 33996830›Full record

ArticleFrontiers in cell and developmental biology2021

Association of Cancer Stem Cell Radio-Resistance Under Ultra-High Dose Rate FLASH Irradiation With Lysosome-Mediated Autophagy.

Gen Yang, Chunyang Lu, Zhusong Mei, Xiaoyi Sun, Jintao Han, Jing Qian, Yulan Liang, Zhuo Pan, Defeng Kong, Shirui Xu and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  6. [Mechanistic research progress on radiotherapy resistance of cancer stem cells].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
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  18. Targeting the organelle for radiosensitization in cancer radiotherapy.Asian journal of pharmaceutical sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 1 country.

Gen YangState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Chunyang LuState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Zhusong MeiState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Xiaoyi SunState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Jintao HanState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Jing QianTeaching and Research Section of Nuclear Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Yulan LiangState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Zhuo PanState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Defeng KongState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Shirui XuState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Zhipeng LiuState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Ying GaoState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Guijun QiState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Yinren ShouState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Shiyou ChenState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Zhengxuan CaoState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Ye ZhaoTeaching and Research Section of Nuclear Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Chen LinState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Yanying ZhaoState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Yixing GengState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Wenjun MaState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
Xueqing YanState Key Laboratory of Nuclear Physics and Technology, School of Physics, CAPT, Peking University, Beijing, China.
State Key Laboratory of Nuclear Physics and TechnologyPeking University · CNAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cell (CSC) is thought to be the major cause of radio-resistance and relapse post radiotherapy (RT). Recently ultra-high dose rate "FLASH-RT" evokes great interest for its decreasing normal tissue damages while maintaining tumor responses compared with conventional dose rate RT. However, the killing effect and mechanism of FLASH irradiation (FLASH-IR) on CSC and normal cancer cell are still unclear. Presently the radiation induced death profile of CSC and normal cancer cell were studied. Cells were irradiated with FLASH-IR (∼10

Indexed as

apoptosisautophagycancer stem cellDNA damageFLASHlysosomenecrosisultra-high dose rate irradiation

Identifiers

PMID33996830
PMCPMC8116574
OpenAlexW3158853680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.