ArticleFrontiers in bioengineering and biotechnology2021
3D Printed Poly(ε-Caprolactone)/Meniscus Extracellular Matrix Composite Scaffold Functionalized With Kartogenin-Releasing PLGA Microspheres for Meniscus Tissue Engineering.
Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Meniscus Tissue Engineering Scaffolds: Biomaterials, Biofabrication, and Translation.Polymers · 2026Review
- Toward functional integration of 3D-printed meniscal scaffolds: A materials-driven systematic review of preclinical evidence and translational framework.Journal of experimental orthopaedics · 2026Review
- Integrated strategies in meniscus tissue engineering: from biomaterials to stem cell-driven regeneration.Frontiers in bioengineering and biotechnology · 2026Review
- Platelet rich plasma applications in orthopedics: A review of recent advances.World journal of orthopedics · 2025Review
- Brick by Brick the Wall Is Being Built: Particle-Based Scaffolds for Regenerative Medicine.Polymers · 2025Review
- Bionic scaffolds with integrated structural components based on low-temperature deposition manufacturing 3D printing technology for the treatment of meniscus defects.Bioengineering & translational medicine · 2025Article
- Development and Characterization of a Polycaprolactone/Graphene Oxide Scaffold for Meniscus Cartilage Regeneration Using 3D Bioprinting.Pharmaceutics · 2025Article
- Concept and Evolution in 3D Printing for Excellence in Healthcare.Current medicinal chemistry · 2025Review
- Microspheres for 3D bioprinting: a review of fabrication methods and applications.Frontiers in bioengineering and biotechnology · 2025Review
- Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review.Bioactive materials · 2025Review
- Exercise Induced Endothelial Mesenchymal Transition (EndMT) Facilitates Meniscal Fibrocartilage Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cartilage lacuna-biomimetic hydrogel microspheres endowed with integrated biological signal boost endogenous articular cartilage regeneration.Bioactive materials · 2024Article
- Long-Term Survival and Regeneration Following Transplantation of 3D-Printed Biodegradable PCL Tracheal Grafts in Large-Scale Porcine Models.Bioengineering (Basel, Switzerland) · 2024Article
- Functional meniscus reconstruction with biological and biomechanical heterogeneities through topological self-induction of stem cells.Bioactive materials · 2024Article
- Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives.Gels (Basel, Switzerland) · 2024Review
- From the microspheres to scaffolds: advances in polymer microsphere scaffolds for bone regeneration applications.Biomaterials translational · 2024Review
- Designing molecules: directing stem cell differentiation.Frontiers in bioengineering and biotechnology · 2024Review
- Rationalized design to explore the full potential of PLGA microspheres as drug delivery systems.Drug delivery · 2023Article
- Kartogenin delivery systems for biomedical therapeutics and regenerative medicine.Drug delivery · 2023Review
- Recent advances in 3D bioprinted cartilage-mimicking constructs for applications in tissue engineering.Materials today. Bio · 2023Review
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Authors and funding
13 authors.
Funding
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Abstract
Meniscus tissue engineering (MTE) aims to fabricate ideal scaffolds to stimulate the microenvironment for recreating the damaged meniscal tissue. Indeed, favorable mechanical properties, suitable biocompatibility, and inherent chondrogenic capability are crucial in MTE. In this study, we present a composite scaffold by 3D printing a poly(ε-caprolactone) (PCL) scaffold as backbone, followed by injection with the meniscus extracellular matrix (MECM), and modification with kartogenin (KGN)-loaded poly(lactic-co-glycolic) acid (PLGA) microsphere (μS), which serves as a drug delivery system. Therefore, we propose a plan to improve meniscus regeneration via KGN released from the 3D porous PCL/MECM scaffold. The final results showed that the hydrophilicity and bioactivity of the resulting PCL/MECM scaffold were remarkably enhanced.
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