Evidence map›Paper›PMID 33996744›Full record

ArticleFrontiers in chemistry2021

Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (

Annalisa Tito, Antonio Colantuono, Luciano Pirone, Emilia Pedone, Daniela Intartaglia, Giuliana Giamundo, Ivan Conte, Paola Vitaglione, Fabio Apone

Open access · goldAbstract read
In one paragraph

Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 97 citations in OpenAlex.

  1. Trial
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  7. International journal of molecular sciences · 2025
    Article
  8. Impact of Glucose, Inflammation and Phytochemicals onAntioxidants (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. The Effect of Pomegranate Tea on the Clinical Outcomes and Symptom Alleviation in COVID-19 Patients: A Double-Blind Randomized Clinical Trial.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  13. Computational andFrontiers in pharmacology · 2025
    Article
  14. Article
  15. Investigation of phytochemicals isolated from selected Saudi medicinal plants as natural inhibitors of SARS CoV-2 main protease: In vitroSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  16. Review
  17. Current therapeutic research, clinical and experimental · 2024
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Annalisa TitoArterra Bioscience SPA, Naples, Italy.
Antonio ColantuonoArterra Bioscience SPA, Naples, Italy.
Luciano PironeInstitute of Biostructures and Bioimaging, National Research Council, Naples, Italy.
Emilia PedoneInstitute of Biostructures and Bioimaging, National Research Council, Naples, Italy.
Daniela IntartagliaTelethon Institute of Genetics and Medicine, Pozzuoli, Italy.
Giuliana GiamundoDepartment of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
Ivan ConteTelethon Institute of Genetics and Medicine, Pozzuoli, Italy.
Paola VitaglioneDepartment of Agricultural Science, University of Naples Federico II, Portici, Italy.
Fabio AponeArterra Bioscience SPA, Naples, Italy.
Telethon Institute Of Genetics And Medicine · ITUniversity of Naples Federico II · ITInstitute of Biostructure and Bioimaging · ITNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant extracts are rich in bioactive compounds, such as polyphenols, sesquiterpenes, and triterpenes, which potentially have antiviral activities. As a consequence of the coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, thousands of scientists have been working tirelessly trying to understand the biology of this new virus and the disease pathophysiology, with the main goal of discovering effective preventive treatments and therapeutic agents. Plant-derived secondary metabolites may play key roles in preventing and counteracting the rapid spread of SARS-CoV-2 infections by inhibiting the activity of several viral proteins, in particular those involved in the virus entry into the host cells and its replication. Using

Indexed as

ACE2COVID-19polyphenolspomegranate peelspomegranate (Punica granatum L.) peel extractsSARS-CoV-2

Identifiers

PMID33996744
PMCPMC8114579
OpenAlexW3159890940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.