Evidence map›Paper›PMID 33996738›Full record

ArticleFrontiers in chemistry2021

Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against

Erik Hembre, Julie V Early, Joshua Odingo, Catherine Shelton, Olena Anoshchenko, Junitta Guzman, Lindsay Flint, Devon Dennison, Matthew B McNeil, Aaron Korkegian and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Erik HembreLilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States.
Julie V EarlyTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, United States.
Joshua OdingoTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, United States.
Catherine SheltonTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, United States.
Olena AnoshchenkoTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, United States.
Junitta GuzmanTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, United States.
Lindsay FlintTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, United States.
Devon DennisonTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, United States.
Matthew B McNeilTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, United States.
Aaron KorkegianTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, United States.
Yulia OvechkinaTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, United States.
Paul OrnsteinApollo Drug Discovery Consulting, LLC, Northbrook, IL, United States.
Thierry MasquelinLilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States.
Philip A HipskindLilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States.
Tanya ParishTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The identification and development of new anti-tubercular agents are a priority research area. We identified the trifluoromethyl pyrimidinone series of compounds in a whole-cell screen against

Indexed as

anti-tubercularbactericidal abilitypyrimidinonestuberculosiswhole cell activity

Identifiers

PMID33996738
PMCPMC8117417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.