Evidence map›Paper›PMID 33996673›Full record

ArticleFrontiers in pediatrics2021

Integrating Population Variants and Protein Structural Analysis to Improve Clinical Genetic Diagnosis and Treatment in Nephrogenic Diabetes Insipidus.

Panli Liao, Tianchao Xiang, Hongxia Li, Ye Fang, Xiaoyan Fang, Zhiqing Zhang, Qi Cao, Yihui Zhai, Jing Chen, Linan Xu and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Case Report of Nephrogenic Diabetes Insipidus with a Novel Mutation in theInternational journal of molecular sciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 1 country.

Panli LiaoDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Tianchao XiangDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Hongxia LiTongji Medical College, Wuhan Children's Hospital, Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science and Technology, Wuhan, China.
Ye FangDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Xiaoyan FangDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Zhiqing ZhangDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Qi CaoDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Yihui ZhaiDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Jing ChenDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Linan XuDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Jialu LiuDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Xiaoshan TangDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Xiaorong LiuDepartment of Nephrology, Beijing Children's Hospital Affiliated to Capital University of Medical Science, Beijing, China.
Xiaowen WangTongji Medical College, Wuhan Children's Hospital, Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science and Technology, Wuhan, China.
Jiangwei LuanTongji Medical College, Wuhan Children's Hospital, Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science and Technology, Wuhan, China.
Qian ShenDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Lizhi ChenDepartment of Pediatric, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xiaoyun JiangDepartment of Pediatric, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Duan MaKey Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Hong XuDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Jia RaoDepartment of Nephrology, National Pediatric Medical Center of China, Children's Hospital of Fudan University, Shanghai, China.
Fudan University · CNChildren's Hospital of Fudan University · CNHuazhong University of Science and Technology · CNWuhan Children's Hospital · CNBeijing Children’s Hospital · CNSun Yat-sen University · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital nephrogenic diabetes insipidus (NDI) is a rare genetic disorder characterized by renal inability to concentrate urine. We utilized a multicenter strategy to investigate the genotype and phenotype in a cohort of Chinese children clinically diagnosed with NDI from 2014 to 2019. Ten boys from nine families were identified with mutations in

Indexed as

AQP2AVPR2genomicsnephrogenic diabetes insipidusprotein structure

Identifiers

PMID33996673
PMCPMC8116627
OpenAlexW3159383582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.