ArticleFrontiers in cellular and infection microbiology2021
Biliary Microbiota in Choledocholithiasis and Correlation With Duodenal Microbiota.
Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Biliary tract microbes and common bile duct stones: current status and prospects.Frontiers in microbiology · 2026Review
- Microbial dysbiosis in cholangiocarcinoma.Frontiers in microbiology · 2026Review
- Biliary microbiome profiling via 16 S rRNA amplicon sequencing in patients with cholangiocarcinoma, pancreatic carcinoma and choledocholithiasis.Scientific reports · 2025Article
- Advances in research on the role of gut microbiota in the pathogenesis and precision management of gallstone disease.Frontiers in medicine · 2025Review
- Common bile duct exploration with choledochotomy and primary repair during pregnancy: Case Report.Frontiers in medicine · 2025Article
- Identification and characterization of bile microbiota in patients with biliary obstructive diseases using next-generation sequencing of 16S rRNA and ITS.Frontiers in cellular and infection microbiology · 2025Article
- Association of biliary microflora dysbiosis with cholangiocarcinoma: a single-center study.Frontiers in microbiology · 2025Article
- Research progress on the role of microbiota in the pathogenesis of gallstone disease.Frontiers in microbiology · 2025Review
- Characterization of biliary and duodenal microbiota in patients with primary and recurrent choledocholithiasis.Health information science and systems · 2024Article
- Review
- The dysregulation of biliary tract microflora is closely related to primary choledocholithiasis: a multicenter study.Scientific reports · 2024Article
- Escherichia coli-Induced cGLIS3-Mediated Stress Granules Activate the NF-κB Pathway to Promote Intrahepatic Cholangiocarcinoma Progression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Variability of bile bacterial profiles and drug resistance in patients with choledocholithiasis combined with biliary tract infection: a retrospective study.Gastroenterology report · 2024Article
- Temporal Shifts in Etiological Agents and Antibiotic Resistance Patterns of Biliary Tract Infections in Sichuan Province, China (2017-2023).Infection and drug resistance · 2024Article
- Elevated plasma and bile levels of corisin, a microbiota-derived proapoptotic peptide, in patients with severe acute cholangitis.Gut pathogens · 2023Article
- Ingesta-associated choledocholithiasis in horses: 2 cases and literature review.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023Review
- Gastrointestinal microbiome and cholelithiasis: Current status and perspectives.World journal of gastroenterology · 2023Review
- Characteristics and metabolic potential of biliary microbiota in patients with giant common bile duct stones.Frontiers in cellular and infection microbiology · 2023Article
- Profiles of biliary microbiota in biliary obstruction patients withFrontiers in cellular and infection microbiology · 2023Article
- ABO-Incompatible Liver Transplantation under the Desensitization Protocol with Rituximab: Effect on Biliary Microbiota and Metabolites.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The pathogenesis of choledocholithiasis is closely related to the role of bacteria. However, little is known about the predictive role of bile bacteria in clinical conditions of patients and the compositional and functional characteristics of biliary microbiota in choledocholithiasis. Methods: To investigate the predictive value of biliary bacteria, clinical data of 488 patients with choledocholithiasis were collected. The predictive value of common bile bacteria to patients' clinical conditions was analyzed by logistic regression. Samples of bile and corresponding duodenal juice from 10 selected patients with choledocholithiasis were obtained, and the composition and function of microbial communities were analyzed based on Results: The clinical conditions of patients with choledocholithiasis, such as recurrence, the severity of acute cholangitis, and duration of hospital stay were closely related to different species of bile bacteria as well as antimicrobial-resistant bacteria. Employing Conclusion: Our study first demonstrates the predictive contribution of biliary bacteria to the clinical conditions of patients with choledocholithiasis, and then it offers new insights into the compositional and functional features of biliary and duodenal microbiota. Similarities between biliary and duodenal microbiota support the theory of bacterial duodenal-biliary reflux in patients with choledocholithiasis. Meanwhile, when it is impracticable to obtain a bile sample, duodenal juice may be used as an alternative for bacterial culture and susceptibility tests.
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