Evidence map›Paper›PMID 33996583›Full record

ArticleFrontiers in oncology2021

Radiomics-Based Features for Prediction of Histological Subtypes in Central Lung Cancer.

Huanhuan Li, Long Gao, He Ma, Dooman Arefan, Jiachuan He, Jiaqi Wang, Hu Liu

Abstract read
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Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Huanhuan LiDepartment of Radiology, The First Hospital of China Medical University, Shenyang, China.
Long GaoCollege of Computer, National University of Defense Technology, Changsha, China.
He MaSino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, China.
Dooman ArefanImaging Research Division, Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States.
Jiachuan HeDepartment of Radiology, The First Hospital of China Medical University, Shenyang, China.
Jiaqi WangDepartment of Radiology, The First Hospital of China Medical University, Shenyang, China.
Hu LiuDepartment of Radiology, The First Hospital of China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the effectiveness of radiomic features on classifying histological subtypes of central lung cancer in contrast-enhanced CT (CECT) images. MATERIALS AND

methodsA total of 200 patients with radiologically defined central lung cancer were recruited. All patients underwent dual-phase chest CECT, and the histological subtypes (adenocarcinoma (ADC), squamous cell carcinoma (SCC), small cell lung cancer (SCLC)) were confirmed by histopathological samples. 107 features were used in five machine learning classifiers to perform the predictive analysis among three subtypes. Models were trained and validated in two conditions: using radiomic features alone, and combining clinical features with radiomic features. The performance of the classification models was evaluated by the area under the receiver operating characteristic curve (AUC).

resultsThe highest AUCs in classifying ADC vs. SCC, ADC vs. SCLC, and SCC vs. SCLC were 0.879, 0.836, 0.783, respectively by using only radiomic features in a feedforward neural network.

conclusionOur study indicates that radiomic features based on the CECT images might be a promising tool for noninvasive prediction of histological subtypes in central lung cancer and the neural network classifier might be well-suited to this task.

Indexed as

central lung cancercomputed tomographyhistological subtypeneural networkradiomics

Identifiers

PMID33996583
PMCPMC8117140

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.