ArticleFrontiers in oncology2021
Adverse Prognostic Impact of Postoperative Complications After Gastrectomy for Patients With Stage II/III Gastric Cancer: Analysis of Prospectively Collected Real-World Data.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 43 citations in OpenAlex.
- Disparities in outcomes and costs of gastrectomy for gastric cancer among patients with depression and anxiety.Surgical oncology insight · 2026Article
- A unified framework for postoperative complications after gastrectomy for gastric cancer: insights from the Korean Quality Improvement Platform in Surgery program.Annals of surgical treatment and research · 2026Article
- Long-Term Outcomes of Minimally Invasive Total Gastrectomy for Locally Advanced Gastric Cancer.Annals of surgical oncology · 2026Article
- Stomach cancer elective surgery morbidity and mortality at 90-Day (Hold Study): a prospective, international collaborative cohort study.Langenbeck's archives of surgery · 2025Article
- Splenic Salvage Following Iatrogenic Splenic Artery Injury Post-gastrectomy.Indian journal of surgical oncology · 2024Article
- Risk factors of postoperative complications and their effect on survival after laparoscopic gastrectomy for gastric cancer.Annals of gastroenterological surgery · 2024Article
- Article
- The Impact of Different Types of Complications on Long-Term Survival After Total Gastrectomy for Gastric Cancer.Journal of gastric cancer · 2023Article
- Prognostic impacts of participation in prospective surgical clinical trials on surgical outcomes in gastric cancer patients.Scientific reports · 2023Article
- A novel nomogram based on the prognostic nutritional index for predicting postoperative outcomes in patients with stage I-III gastric cancer undergoing robotic radical gastrectomy.Frontiers in surgery · 2022Article
- Impact of Type of Postoperative Complications on Long-Term Survival of Gastric Cancer Patients: Results From a High-Volume Institution in China.Frontiers in oncology · 2021Article
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10 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of postoperative complications on the prognosis of gastric cancer remains controversial. This study aimed to evaluate the relationship between postoperative complications and long-term survival in patients undergoing gastrectomy for stage II/III gastric cancer.
methodsSome 939 patients underwent curative gastrectomy for stage II/III gastric cancer were identified from real-world data prospectively collected between 2013 and 2015. We divided patients according to the presence of serious complications, specifically, Clavien-Dindo grade III or higher complications or those causing a hospital stay of 15 days or longer.
resultsSerious complications occurred in 125 (13.3%) patients. Patients without serious complications (64.3%) completed adjuvant chemotherapy significantly more than patients with serious complications (37.6%; p<0.001). The 5-year overall survival(OS) rate was 58.1% and recurrence-free survival(RFS) rate was 58.1% in patients with serious complications, which were significantly worse than those of patients without serious complications (73.4% and 74.7%, respectively; p<0.001 for both). In stage II, once patients completed adjuvant chemotherapy adequately, the OS and RFS of patients with serious complications did not differ from those without serious complications. However, in stage III, the patients with serious complications showed a worse OS even after completion of adequate adjuvant chemotherapy.
conclusionSerious complications after gastrectomy had a negative impact on the prognosis of stage II/III gastric cancer patients. Serious complications worsen the survival in association with inadequate adjuvant chemotherapy. Efforts to reduce serious complications, as well as support adequate chemotherapy through proper management of serious complications, would improve the prognosis of stage II/III gastric cancer patients.
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