Evidence map›Paper›PMID 33996503›Full record

ArticleToxicology reports2021

Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs.

Lucille Lumley, Fu Du, Brenda Marrero-Rosado, Michael Stone, Zora-Maya Keith, Caroline Schultz, Kimberly Whitten, Katie Walker, Cindy Acon-Chen, Linnzi Wright and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lucille LumleyU.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, United States.
Fu DuFD NeuroTechnologies, Inc., Columbia, MD, United States.
Brenda Marrero-RosadoU.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, United States.
Michael StoneU.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, United States.
Zora-Maya KeithU.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, United States.
Caroline SchultzU.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, United States.
Kimberly WhittenU.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, United States.
Katie WalkerU.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, United States.
Cindy Acon-ChenU.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, United States.
Linnzi WrightU.S. Army Combat Capabilities Development Command Chemical Biological Center, Aberdeen Proving Ground, MD, United States.
Tsung-Ming ShihU.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, United States.
United States Army · USUnited States Army Combat Capabilities Development Command · US

Funding

Soman-induced neuropathology in Gottingen minipig: large animal model assessment for MCMR21NS110556 · NINDS · GENEVA FOUNDATION · PI LANGE, LUCILLE · 2019 to 2020
$340k
NINDS NIH HHS R21 NS110556
6 · The paper itself

Abstract

Animal models are essential for evaluating the toxicity of chemical warfare nerve agents (CWNAs) to extrapolate to human risk and are necessary to evaluate the efficacy of medical countermeasures. The Göttingen minipig is increasingly used for toxicological studies because it has anatomical and physiological characteristics that are similar to those of humans. Our objective was to determine whether the minipig would be a useful large animal model to evaluate the toxic effects of soman (GD). We determined the intramuscular (IM) median lethal dose (LD

Indexed as

Chemical warfare nerve agentGöttingen minipigMedian lethal doseSeizureVisual system

Identifiers

PMID33996503
PMCPMC8095108
OpenAlexW3155841276

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.