Evidence map›Paper›PMID 33996437›Full record

ArticleLeukemia research reports2021

Amyloid arthropathy in smoldering myeloma: Do not take it lightly.

Eli Muchtar, Rebecca L King, Ellen D McPhail, Matthew P Thorpe, Wilson Gonsalves, Floranne Ernste, Martha Grogan, Angela Dispenzieri, Morie A Gertz

Erratum issuedOpen access · goldAbstract readCase Reports
In one paragraph

Article in Leukemia research reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Eli MuchtarDivision of Hematology Mayo Clinic Rochester, MN, United States.
Rebecca L KingDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.
Ellen D McPhailDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.
Matthew P ThorpeDepartment of Radiology, Mayo Clinic, Rochester, MN, United States.
Wilson GonsalvesDivision of Hematology Mayo Clinic Rochester, MN, United States.
Floranne ErnsteDivision of Rheumatology, Mayo Clinic, Rochester, MN, United States.
Martha GroganDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States.
Angela DispenzieriDivision of Hematology Mayo Clinic Rochester, MN, United States.
Morie A GertzDivision of Hematology Mayo Clinic Rochester, MN, United States.
Mayo Clinic in Arizona · US

Funding

Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Peter Leif Bergsagel · 2015 to 2026
$25.5M
NCI NIH HHS P50 CA186781
6 · The paper itself

Abstract

We report a case of smoldering multiple myeloma patient who developed signs and symptoms consistent with polyarthritis. A PET-CT demonstrated marked FDG activity in multiple joints, concerning for inflammatory arthritis. Arthrocentesis from the glenohumeral joint was consistent with inflammatory synovial fluid with no evidence for infection or crystals. Congo-red stain of the synovial fluid was positive, and mass-spectrometry based amyloid typing was consistent with wild-type transthyretin type. The patient responded instantly to glucocorticoids. This case reports highlights the feasibility of non-tissue diagnosis of amyloidosis using body fluids and underscores the importance of accurate typing to avoid erroneous treatment.

Indexed as

AmyloidosisArthrocentesisArthropathicCongo red

Identifiers

PMID33996437
PMCPMC8105656
OpenAlexW3159047062

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.