Evidence map›Paper›PMID 33996230›Full record

ArticleBiomedical optics express2021

Understanding the sources of errors in

Roujia Wang, Daniel A Alvarez, Brian T Crouch, Aditi Pilani, Christopher Lam, Caigang Zhu, Philip Hughes, David Katz, Timothy Haystead, Nirmala Ramanujam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Roujia WangDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.ORCID https://orcid.org/0000-0002-4081-4098
Daniel A AlvarezDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
Brian T CrouchDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.ORCID https://orcid.org/0000-0002-2310-6110
Aditi PilaniDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
Christopher LamDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
Caigang ZhuDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
Philip HughesDepartment of Pharmacology and Cancer Biology, School of Medicine, Duke University, Durham, North Carolina 27708, USA.
David KatzDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
Timothy HaysteadDepartment of Pharmacology and Cancer Biology, School of Medicine, Duke University, Durham, North Carolina 27708, USA.
Nirmala RamanujamDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
Duke University · USUniversity of Kentucky · US

Funding

Development of CapCell Scope for Metabolic Imaging of Tissue Heterogeneity and Therapy ResponseR01EB028148 · NIBIB · DUKE UNIVERSITY · PI ANDREI GOGA, Nirmala Ramanujam · 2019 to 2026
$4.0M
A novel strategy to see and treat breast cancer: translation to intra-operative breast margin assessmentR21EB025008 · NIBIB · DUKE UNIVERSITY · PI RAMANUJAM, NIRMALA · 2017 to 2018
$424k
NIBIB NIH HHS R01 EB028148NIBIB NIH HHS R21 EB025008
6 · The paper itself

Abstract

Overexpression of heat shock protein 90 (Hsp90) on the surface of breast cancer cells makes it an attractive molecular biomarker for breast cancer diagnosis. Before a ubiquitous diagnostic method can be established, an understanding of the systematic errors in Hsp90-based imaging is essential. In this study, we investigated three factors that may influence the sensitivity of

Identifiers

PMID33996230
PMCPMC8086448
OpenAlexW3138940598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.