ArticleBiomedical optics express2021
Limited-angle tomographic phase microscopy utilizing confocal scanning fluorescence microscopy.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Measuring Molecular Mass Densities at Subcellular Resolution Using Optical Diffraction Tomography.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Dynamic tracking of onion-like carbon nanoparticles in cancer cells using limited-angle holographic tomography with self-supervised learning.Biomedical optics express · 2024Article
- Common methods in mitochondrial research (Review).International journal of molecular medicine · 2022Article
- Dynamic Tomographic Phase Microscopy by Double Six-Pack Holography.ACS photonics · 2022Article
- Common-path intrinsically achromatic optical diffraction tomography.Biomedical optics express · 2021Article
- Application of quantitative cell imaging using label-free optical diffraction tomography.Biophysics and physicobiology · 2021Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a multimodal imaging technique, combining tomographic phase microscopy with limited angular projection range and number, and two-channel spinning-disk confocal scanning fluorescence microscopy. This technique allows high-accuracy 3D refractive index (RI) profiling of live cells in spite of the missing projections. The cellular outer shape and its interior organelles measured by the confocal fluorescence imaging not only specify the cell in molecular levels, but also provide the 3D distributions of the whole cell as well as its organelles. We take these additional 3D morphological details as constraints in Gerchberg-Papoulis-based optical diffraction tomography algorithm. We then obtain an accurate 3D RI tomogram, even with a sparse angular range having a small number of perspective projections, otherwise providing low-accuracy RI reconstruction. Then, we obtain both cellular molecular specificity and inner RI values of the cell and its organelles. We compare the reconstructed 3D RI profiles of various samples, demonstrating the superiority of the proposed technique.
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Registered trials
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