Evidence map›Paper›PMID 33996196›Full record

ArticleACS catalysis2019

Oscillatory Active-site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase.

Philip Pagano, Qi Guo, Chethya Ranasinghe, Evan Schroeder, Kevin Robben, Florian Häse, Hepeng Ye, Kyle Wickersham, Alán Aspuru-Guzik, Dan T Major and 3 more

Open access · greenAbstract read
In one paragraph

Article in ACS catalysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

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  10. Changing the Electron Acceptor Specificity ofInternational journal of molecular sciences · 2023
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  13. Direct Biocatalytic Processes for COMolecules (Basel, Switzerland) · 2023
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  14. Article
  15. Increasing Pump-Probe Signal toward Asymptotic Limits.The journal of physical chemistry. B · 2023
    Review
  16. Protein Dynamics and Enzymatic Catalysis.The journal of physical chemistry. B · 2023
    Review
  17. Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Philip PaganoDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, United States.
Qi GuoDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, United States.
Chethya RanasingheDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, United States.
Evan SchroederDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, United States.
Kevin RobbenDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, United States.
Florian HäseDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, United States.
Hepeng YeDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, United States.
Kyle WickershamDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, United States.
Alán Aspuru-GuzikDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, United States.
Dan T MajorChemistry Department, Bar-Ilan University, Ramat Gan 52900, Israel.
Lokesh GakharProtein Crystallography Facility and Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, United States.
Amnon KohenDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, United States.
Christopher M CheatumDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, United States.
University of Iowa · USBar-Ilan University · ILCanadian Institute for Advanced Research · CAHarvard University · US

Funding

The Role of fs-ps Dynamics in Enzymatic H-TransferR01GM079368 · NIGMS · UNIVERSITY OF IOWA · PI CHEATUM, CHRISTOPHER M · 2010 to 2014
$1.4M
NIGMS NIH HHS R01 GM079368
6 · The paper itself

Abstract

Thermal motions of enzymes have been invoked to explain the temperature dependence of kinetic isotope effects (KIE) in enzyme-catalyzed hydride transfers. Formate dehydrogenase (FDH) from

Indexed as

dynamicsenzyme catalysisformate dehydrogenaseKIEoscillationProtein dynamicstwo-dimensional infrared spectroscopy

Identifiers

PMID33996196
PMCPMC8118594
OpenAlexW2981844715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.