Evidence map›Paper›PMID 33996171›Full record

ArticleImmune network2021

Modulation of Pro-inflammatory and Anti-inflammatory Cytokines in the Fat by an Aloe Gel-based Formula, QDMC, Is Correlated with Altered Gut Microbiota.

Jinho An, Heetae Lee, Sungwon Lee, Youngcheon Song, Jiyeon Kim, Il Ho Park, Hyunseok Kong, Kyungjae Kim

Open access · diamondAbstract read
In one paragraph

Article in Immune network, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Frontiers in microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jinho AnCollege of Pharmacy, Sahmyook University, Seoul 01795, Korea.ORCID https://orcid.org/0000-0001-7101-7115
Heetae LeeCollege of Pharmacy, Sahmyook University, Seoul 01795, Korea.ORCID https://orcid.org/0000-0001-5105-8841
Sungwon LeeCollege of Pharmacy, Sahmyook University, Seoul 01795, Korea.ORCID https://orcid.org/0000-0002-0266-5001
Youngcheon SongCollege of Pharmacy, Sahmyook University, Seoul 01795, Korea.ORCID https://orcid.org/0000-0002-4350-6330
Jiyeon KimClimacteric Natural Products Research Institute, Sahmyook University, Seoul 01795, Korea.ORCID https://orcid.org/0000-0002-0673-0798
Il Ho ParkCollege of Pharmacy, Sahmyook University, Seoul 01795, Korea.ORCID https://orcid.org/0000-0001-5778-6110
Hyunseok KongClimacteric Natural Products Research Institute, Sahmyook University, Seoul 01795, Korea.ORCID https://orcid.org/0000-0002-4880-6340
Kyungjae KimCollege of Pharmacy, Sahmyook University, Seoul 01795, Korea.ORCID https://orcid.org/0000-0002-0943-9306
Sahmyook University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal inflammatory responses are closely associated with intestinal microbial dysbiosis. Oral administration of Qmatrix-diabetes-mellitus complex (QDMC), an Aloe gel-based formula, has been reported to improve inflammation in type 2 diabetic mice; however, the role of the gut microbiota in ameliorating efficacy of QDMC remains unclear. We investigated the effect of QDMC on the gut microbiota in a type 2 diabetic aged mouse model that was administered a high-fat diet. Proinflammatory (TNF-α and IL-6) and anti-inflammatory (IL-4 and IL-10) cytokine levels in the fat were normalized via oral administration of QDMC, and relative abundances of

Indexed as

Anti-inflammatoryGut microbiotaProinflammatoryQmatrix-diabetes-mellitus complexType 2 diabetes

Identifiers

PMID33996171
PMCPMC8099612
OpenAlexW3158316801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.