Evidence map›Paper›PMID 33996076›Full record

ArticleTherapeutic advances in infectious disease

Cryptococcosis complicating diabetes mellitus: a scoping review.

Lauryn Nsenga, Jonathan Kajjimu, Ronald Olum, Sandra Ninsiima, Andrew Peter Kyazze, Phillip Ssekamatte, Davis Kibirige, Joseph Baruch Baluku, Irene Andia-Biraro, Felix Bongomin

Open access · goldAbstract readScoping Review
In one paragraph

Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  9. 'WhenTherapeutic advances in chronic disease · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Lauryn NsengaSchool of Medicine, Kabale University, Kabale, Uganda.
Jonathan KajjimuFaculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Ronald OlumDepartment of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Sandra NinsiimaDepartment of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Andrew Peter KyazzeDepartment of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Phillip SsekamatteDepartment of Immunology and Molecular Biology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda.
Davis KibirigeDepartment of Medicine, Uganda Martyrs Lubaga Hospital, Kampala, Uganda.
Joseph Baruch BalukuDivision of Pulmonology, Kiruddu National Referral Hospital, Kampala, Uganda.
Irene Andia-BiraroDepartment of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Felix BongominDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, P.O. Box, 166, Gulu, Uganda.ORCID https://orcid.org/0000-0003-4515-8517
Makerere University · UGGulu University · UGKabale University · UGMbarara University of Science and Technology · UGMildmay Uganda · UGRubaga Hospital · UG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA better understanding of the epidemiology of cryptococcal infection in HIV-negative individuals is an international research interest. Immune dysfunction in diabetes mellitus (DM) significantly increases the risk of acquiring and reactivation of infection due to

objectiveThe objective of this study was to determine the clinical characteristics and outcomes of cryptococcal infections in persons living with DM.

methodsMEDLINE (via PubMed), EMBASE, and the Cochrane Library databases were searched in November 2020. The searches covered the period between 1980 and 2020.We included studies that reported confirmed cryptococcosis in patients with DM. Reference lists of included articles were also searched, and additional studies were included if appropriate. No language restriction was applied. Single case reports, case series and original articles were included whereas review articles were excluded.

resultsA total of 28 studies (24 single case reports, 4 retrospectives) were included involving 47 unique patients from Asia (17 cases), North America (six cases), South America (three cases) and Africa (two cases). Men constituted 75% (

conclusionA wide spectrum of cryptococcal infections with varying severity occurs in DM. Mortality remains unacceptably high. There is a need for more studies to characterize better cryptococcal disease in DM.

Indexed as

clinical characteristicscryptococcosisdiabetes mellitusmortality

Identifiers

PMID33996076
PMCPMC8111545
OpenAlexW3160025491

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.