Articlei-Perception
Improved Odor Identification Ability and Increased Regional Gray Matter Volume After Olfactory Training in Patients With Idiopathic Olfactory Loss.
Article in i-Perception. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Does Olfactory Training Improve Brain Function and Cognition? A Systematic Review.Neuropsychology review · 2024Pooled it
- Article
- Functional but Not Structural Brain Changes After Olfactory Training in Women With COVID-19-Associated Olfactory Dysfunction.The Laryngoscope · 2025Article
- Cues for odor naming affect performance and brain connectivity.Frontiers in human neuroscience · 2025Article
- Recovery rates and long-term olfactory dysfunction following COVID-19 infection.World journal of otorhinolaryngology - head and neck surgery · 2024Review
- Olfactory Function and Olfactory Disorders.Laryngo- rhino- otologie · 2023Article
- Altered Grey Matter-Brain Healthcare Quotient: Interventions of Olfactory Training and Learning of Neuroplasticity.Life (Basel, Switzerland) · 2023Article
- Overnight olfactory enrichment using an odorant diffuser improves memory and modifies the uncinate fasciculus in older adults.Frontiers in neuroscience · 2023Review
- COVID-19 and olfactory dysfunction: a looming wave of dementia?Journal of neurophysiology · 2022Review
- Article
- Olfactory loss is a predisposing factor for depression, while olfactory enrichment is an effective treatment for depression.Frontiers in neuroscience · 2022Article
- Research Progress of Olfactory Nerve Regeneration Mechanism and Olfactory Training.Therapeutics and clinical risk management · 2022Review
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic olfactory loss (IOL) is thought as an early marker for neurodegenerative disease. This study investigated the effect of olfactory training (OT) on regional gray matter volume (GMV) among patients with IOL. A total of 24 patients (mean age 64.6 years, 11 male) with IOL and 30 control participants with normal olfaction (mean age 62.6 years, 13 males) were included in the study. Voxel-based morphometry was performed to compare the GMV between patient and control groups. Only the patients received OT (averaged duration 7 months), and a longitudinal approach was used to examine the GMV change from pre- to post-OT. Moreover, the effect of OT on GMV change was explored for patients with different severity of olfactory loss (anosmia vs. hyposmia). Olfactory performance was measured alongside using the "Sniffin' Sticks." Patients had improved odor identification and larger GMV in the bilateral cerebellum, bilateral thalamus, left precentral gyrus, right gyrus rectus, and medial orbitofrontal cortex after OT. However, no correlation was found between changes of odor identification and increased regional GMV. Besides, patients with anosmia, compared with patient with hyposmia, demonstrated increased GMV in the left precuneus, left superior frontal medial cortex, and left midcingulate cortex after OT. The study showed improved odor identification ability among patients with IOL after OT, which is unlikely related to spontaneous recovery. In this specific patient group, the GMV alterations may be associated with factors not directly predicted by the currently performed measurements, but possibly higher order olfactory-related functional changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.