Evidence map›Paper›PMID 33995919›Full record

ReviewComputational and structural biotechnology journal2021

Experimental approaches for investigating ion atmospheres around nucleic acids and proteins.

Binhan Yu, Junji Iwahara

Abstract readReview
In one paragraph

Review in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Ion Adsorption at Surfaces from Local and Global Electroneutrality Constraints.Langmuir : the ACS journal of surfaces and colloids · 2026
    Article
  4. Ion NMR for Biomolecular Systems.Journal of molecular biology · 2025
    Review
  5. Strong field gradients enable NMR-based diffusion measurements for KJournal of magnetic resonance (San Diego, Calif. : 1997) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Binhan YuDepartment of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555-1068, USA.
Junji IwaharaDepartment of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555-1068, USA.

Funding

Dynamics of DNA scanning and recognition by transcription factorsR35GM130326 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Junji Iwahara · 2019 to 2026
$4.2M
NIGMS NIH HHS R35 GM130326
6 · The paper itself

Abstract

Ionic interactions are crucial to biological functions of DNA, RNA, and proteins. Experimental research on how ions behave around biological macromolecules has lagged behind corresponding theoretical and computational research. In the 21st century, quantitative experimental approaches for investigating ionic interactions of biomolecules have become available and greatly facilitated examinations of theoretical electrostatic models. These approaches utilize anomalous small-angle X-ray scattering, atomic emission spectroscopy, mass spectrometry, or nuclear magnetic resonance (NMR) spectroscopy. We provide an overview on the experimental methodologies that can quantify and characterize ions within the ion atmospheres around nucleic acids, proteins, and their complexes.

Indexed as

AES, atomic emission spectroscopyASAXS, anomalous small-angle X-ray scatteringBE, buffer equilibrationDynamicsElectrostatic interactionsICP-MS, inductively coupled plasma mass spectrometryIon atmosphereIonic diffusionNMR, nuclear magnetic resonancePRE, paramagnetic relaxation enhancementSAXS, small-angle X-ray scatteringSpatial distribution

Identifiers

PMID33995919
PMCPMC8102144

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.