Evidence map›Paper›PMID 33995789›Full record

ArticleThe Pan African medical journal2021

The first biological choice in patients with rheumatoid arthritis: data from the Moroccan register of biotherapies.

Meryem Eddaoudi, Samira Rostom, Ihsane Hmamouchi, Imane El Binoune, Bouchra Amine, Redouane Abouqal, Lahsen Achemlal, Fadoua Allali, Imane El Bouchti, Abdellah El Maghraoui and 7 more

Abstract readMulticenter Study
In one paragraph

Article in The Pan African medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Meryem EddaoudiRheumatology Department A, El Ayachi Hospital, Ibn Sina University Hospital, Rabat-Sale, Morocco.
Samira RostomRheumatology Department A, El Ayachi Hospital, Ibn Sina University Hospital, Rabat-Sale, Morocco.
Ihsane HmamouchiLaboratory of Epidemiology and Clinical Research, Faculty of Medicine and Pharmacy, Rabat, Morocco.
Imane El BinouneRheumatology Department A, El Ayachi Hospital, Ibn Sina University Hospital, Rabat-Sale, Morocco.
Bouchra AmineRheumatology Department A, El Ayachi Hospital, Ibn Sina University Hospital, Rabat-Sale, Morocco.
Redouane AbouqalLaboratory of Epidemiology and Clinical Research, Faculty of Medicine and Pharmacy, Rabat, Morocco.
Lahsen AchemlalRheumatology Department, Military Hospital Mohamed V, Ibn Sina University Hospital, Rabat, Morocco.
Fadoua AllaliRheumatology Department B, El Ayachi Hospital, Ibn Sina University Hospital, Rabat-Sale, Morocco.
Imane El BouchtiRheumatology Department, Arrazi Hospital, University Hospital Mohammed VI, Marrakech, Morocco.
Abdellah El MaghraouiRheumatology Medical Office, Rabat, Morocco.
Imad GhozlaniRheumatology Department, University Hospital, Agadir, Morocco.
Hasna HassikouRheumatology Department, Military Hospital, Hassan II University Hospital, Meknes, Morocco.
Taoufik HarzyRheumatology Department, University Hospital Hassan II, Fez, Morocco.
Linda IchchouRheumatology Department, University Hospital Mohammed VI, Oujda, Morocco.
Ouafae MkinsiRheumatology Department, University Hospital Ibn Rochd, Casablanca, Morocco.
Redouane NiamaneRheumatology Department, Military Hospital Avicenne, University Hospital Mohammed VI, Marrakech, Morocco.
Rachid BahiriRheumatology Department A, El Ayachi Hospital, Ibn Sina University Hospital, Rabat-Sale, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionthe aim of our study is to determine, from data of the Moroccan register of biotherapies, the factors influencing the choice of the first prescribed biological treatment.

methodscross-sectional multicenter study including rheumatoid arthritis patients who were initiated the first biological treatment either: Rituximab, an anti-TNF, or Tocilizumab. The determinants related to the patient and disease have been gathered. A univariate and then multivariate analysis to determine the factors associated with the choice of the first bDMARDs was realized.

resultsa total of 225 rheumatoid arthritis patients were included in the Moroccan registry. The mean age was 52 ± 11 years, with female predominance 88% (n = 197). The first prescribed biological treatment was Rituximab 74% (n = 166), the second one was Tocilizumab, 13.6% (n = 31) then comes the anti-TNF in 3

conclusionour study suggests that Rituximab and TNFi are associated with the type of insurance and Tocilizumab is the most prescribed biologic mono-therapy in RA patients. Further studies are needed to confirm these results.

Indexed as

AdultAntibodies, Monoclonal, HumanizedAntirheumatic AgentsArthritis, RheumatoidBiological TherapyCross-Sectional StudiesFemaleHumansMaleMiddle AgedMoroccoRegistriesRetrospective StudiesRituximabTumor Necrosis Factor-alphaAntibodies, Monoclonal, HumanizedAntirheumatic AgentsRituximabtocilizumabTumor Necrosis Factor-alpharheumatoid arthritisRituximabtocilizumabtreatmenttumor necrosis factor inhibitors

Identifiers

PMID33995789
PMCPMC8106777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.