ArticleTheranostics2021
EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer.
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Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
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Who cites it
45 citing papers in PubMed, 83 citations in OpenAlex.
- Single-cell and spatial transcriptomics map lung-adaptive metastasis programs through Exoc4, Cd36-vasculogenic mimicry, and Cxcr2 signaling in triple-negative breast cancer.Cell death & disease · 2026Article
- EGFR-dependent delivery of phosphorylated IGFBP3 by cancer stem cells drives chemotherapy resistance in colorectal cancer.Cell death & disease · 2026Article
- Exploring the Molecular and Genomic Landscape of the Dark Agouti Rat Mammary Adenocarcinoma: Preliminary Insights for Triple-Negative Breast Cancer Modeling.Journal of mammary gland biology and neoplasia · 2026Article
- Circulating Tumor Cells: Emerging Frontiers in Cancer Technology.Expert reviews in molecular medicine · 2026Review
- Quercetin and Citreorosein fromCurrent pharmaceutical design · 2026Article
- Targeting pre-metastatic niche with inhalable dendritic cell vesicles to prevent breast cancer lung metastasis.Journal of nanobiotechnology · 2025Article
- Micropapillary structure: A natural tumor collective invasion model with enhanced stem-like properties.Cancer science · 2025Review
- Article
- Investigating the mechanism of oridonin against triple-negative breast cancer based on network pharmacology and molecular docking.PloS one · 2025Article
- Article
- Bioinformatics Strategy for Investigating the Mechanism of Hispolon in the Treatment of Triple-Negative Breast Cancer withCurrent cancer drug targets · 2025Article
- Clinical significance and heterogeneity of circulating tumor cells and clusters in breast cancer subtypes.PeerJ · 2025Review
- NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer.Molecular cancer · 2024Article
- Circulating tumor cells: from new biological insights to clinical practice.Signal transduction and targeted therapy · 2024Review
- Combination of monensin and erlotinib synergistically inhibited the growth and cancer stem cell properties of triple-negative breast cancer by simultaneously inhibiting EGFR and PI3K signaling pathways.Breast cancer research and treatment · 2024Article
- PA28γ induces dendritic cell maturation and activates T-cell immune responses in oral lichen planus.MedComm · 2024Article
- Systematic optimization and evaluation of culture conditions for the construction of circulating tumor cell clusters using breast cancer cell lines.BMC cancer · 2024Article
- Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature.Discover oncology · 2024Review
- Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets.Molecules (Basel, Switzerland) · 2024Review
- Single-cell RNA sequencing reveals epithelial cells driving brain metastasis in lung adenocarcinoma.iScience · 2024Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Xia LiuDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Valery Adorno-CruzDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ya-Fang ChangThe Ben May Department for Cancer Research, the University of Chicago, Chicago, IL, USA.
Yuzhi JiaDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Madoka KawaguchiLaboratory of Functional Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Nurmaa K DashzevegDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Rokana TaftafDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Erika K RamosDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Emma J SchusterDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Lamiaa El-ShennawyDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Dhwani PatelDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Youbin ZhangDepartment of Medicine, the Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Massimo CristofanilliDepartment of Medicine, the Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Huiping LiuDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Northwestern University · USKyoto University · JP
Funding
University of Kentucky Center for Cancer MetabolismP20GM121327 · NIGMS · UNIVERSITY OF KENTUCKY · PI Jianhang Jia · 2017 to 2026
$25.0MCELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1MCARCINOGENESIS TRAINING PROGRAMT32CA009560 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1986 to 2026
$8.4MTRAINING PROGRAM IN ONCOGENESIS &DEVELOPMENT BIOLOGYT32CA080621 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI EKLUND, ELIZABETH ANN · 2001 to 2018
$4.1MMolecular mechanisms underlying circulating tumor cell aggregationR01CA245699 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIU, HUIPING · 2020 to 2024
$2.0MIdentifying a network of miRNAs and genes that regulate breast tumor metastasisR00CA160638 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIU, HUIPING · 2014 to 2017
$883kNCI NIH HHS R00 CA160638NCI NIH HHS R01 CA245699NCI NIH HHS T32 CA009560NCI NIH HHS T32 CA080621NIGMS NIH HHS P20 GM121327NIGMS NIH HHS T32 GM008061
Abstract
Triple-negative breast cancer (TNBC) is one of the most aggressive and metastatic breast cancer subtypes lacking targeted therapy. Our recent work demonstrated that circulating tumor cell (CTC) clusters and polyclonal metastasis of TNBC are driven by aggregation of CD44
Indexed as
Molecular Targeted TherapyAnimalsAntineoplastic AgentsAntineoplastic Agents, ImmunologicalCell AggregationErbB ReceptorsErlotinib HydrochlorideFemaleGenes, ReporterHumansHyaluronan ReceptorsLung NeoplasmsMiceMicroRNAsNeoplasm ProteinsNeoplastic Cells, CirculatingAntineoplastic AgentsAntineoplastic Agents, ImmunologicalCD44 protein, humanEGFR protein, humanErbB ReceptorsErlotinib HydrochlorideHyaluronan ReceptorsMicroRNAsMIRN30b microRNA, humanNeoplasm ProteinsRNARNA, recombinantcancer stem cellscirculating cancer stem cellcirculating tumor cellsCTC clusterEGFRmetastasis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.