Evidence map›Paper›PMID 33995651›Full record

ArticleTheranostics2021

Inner retinal injury in experimental glaucoma is prevented upon AAV mediated Shp2 silencing in a caveolin dependent manner.

Mojdeh Abbasi, Vivek K Gupta, Nitin Chitranshi, Veer Gupta, Reza Ranjbaran, Rashi Rajput, Kanishka Pushpitha, Devaraj Kb, Yuyi You, Ghasem Hosseini Salekdeh and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Piperine alleviates retinal ischemic injury by mediating the APE1 signaling.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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  8. Article
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  10. Article
  11. Neuroserpin gene therapy inhibits retinal ganglion cell apoptosis and promotes functional preservation in glaucoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
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  13. Review
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Mojdeh AbbasiDepartment of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Vivek K GuptaDepartment of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Nitin ChitranshiDepartment of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Veer GuptaSchool of Medicine, Deakin University, Melbourne, VIC, Australia.
Reza RanjbaranDiagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Rashi RajputDepartment of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Kanishka PushpithaDepartment of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Devaraj KbDepartment of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Yuyi YouDepartment of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Ghasem Hosseini SalekdehDepartment of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran.
Robert G PartonInstitute for Molecular Bioscience and Centre for Microscopy and Microanalysis, The University of Queensland, Queensland 4072, Australia.
Mehdi MirzaeiDepartment of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Stuart L GrahamDepartment of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Deakin University · AUUniversity of Sydney · AUMacquarie University · AUShiraz University of Medical Sciences · IRUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SH2 domain containing tyrosine phosphatase 2 (Shp2; PTPN11) regulates several intracellular pathways downstream of multiple growth factor receptors. Our studies implicate that Shp2 interacts with Caveolin-1 (Cav-1) protein in retinal ganglion cells (RGCs) and negatively regulates BDNF/TrkB signaling. This study aimed to investigate the mechanisms underlying the protective effects of shp2 silencing in the RGCs in glaucomatous conditions.

Indexed as

Genetic TherapyAlpha-GlobulinsAnimalsApoptosisBrain-Derived Neurotrophic FactorCaveolin 1DependovirusDNA, ComplementaryFocal Adhesion Kinase 1Gene Knockdown TechniquesGenes, ReporterGenes, SyntheticGenetic VectorsGlaucomaIntegrin beta1Intraocular PressureAlpha-GlobulinsBdnf protein, mouseBrain-Derived Neurotrophic FactorCaveolin 1chorionic alpha(2)-microglobulinDNA, ComplementaryFocal Adhesion Kinase 1Integrin beta1Membrane GlycoproteinsNtrk2 protein, mouseProtein-Tyrosine KinasesProtein Tyrosine Phosphatase, Non-Receptor Type 11Ptk2 protein, mousePtpn11 protein, mouseReceptor, trkBCaveolinGlaucomaRetinal Ganglion cells, Shp2 phosphataseTrkB.

Identifiers

PMID33995651
PMCPMC8120201
OpenAlexW3157889188

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.