ArticleTherapeutic advances in musculoskeletal disease2021
Ultrasonography predicts the results of labial salivary gland biopsy in patients with suspected Sjögren's syndrome: a matrix risk model.
Article in Therapeutic advances in musculoskeletal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Diagnostic performance of conventional ultrasound and shear wave elastography of the parotid glands in primary Sjögren's syndrome.BMC medical imaging · 2026Article
- Diagnostic Performance of Parotid Shear-Wave Elastography for Predicting Histopathological Positivity in Patients with Suspected Primary Sjögren's Syndrome.Diagnostics (Basel, Switzerland) · 2026Article
- Ultrasound shear wave elastography for assessing minor salivary gland involvement in anti-centromere antibody-positive primary Sjögren's syndrome: a retrospective study.Clinical and experimental medicine · 2024Review
- Non-invasive imaging for predicting labial salivary gland biopsy outcomes in patients with suspected primary Sjögren syndrome.Clinical rheumatology · 2024Article
- Shear wave elastography as a potential additional diagnostic tool in primary Sjögren's syndrome: an observational study.Rheumatology international · 2022Observational
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Authors and funding
11 authors at 1 institution in 1 country.
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Abstract
objectiveAlthough a positive result of labial salivary gland biopsy (LSGB) is critical for the diagnosis of Sjögren's syndrome, rheumatologists prefer assessing the non-invasive objective items and hope to learn the predicted probability of positive LSGB before referring patients with suspected Sjögren's syndrome to receive biopsy. This study aimed to explore the predictive value of combined B-mode ultrasonography (US) and shear-wave elastography (SWE) examination on LSGB results.
methodsA derivation cohort and later a validation cohort of patients with suspected Sjögren's syndrome were recruited. All participants received clinical assessments, B-mode US and SWE examination on bilateral parotid and submandibular glands before LSGB. Positive LSGB was defined by a focus score ⩾1 per 4 mm
resultsIn the derivation cohort of 91 participants, either the total US scores or the total SWE values of four glands significantly distinguished patients with positive LSGB from those with negative results (area under the curve (AUC) = 0.956, 0.825, both
conclusionA novel matrix risk model based on the combined B-mode US and SWE examination can help rheumatologists to make a shared decision with suspected Sjögren's syndrome patients on whether the invasive procedure of LSGB should be performed.
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