Evidence map›Paper›PMID 33995480›Full record

ArticleFrontiers in genetics2021

Dissecting the Roles of LncRNAs in the Development of Periventricular White Matter Damage.

Xinyu Wang, Heng Liu, Xiaoli Liao, Lixing Qiao, Lihua Zhu, Shun Wu, Yan Zhou, Yi Zhang, Bangbang Li, Lili Lin and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Xinyu WangDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Heng LiuDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Xiaoli LiaoDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Lixing QiaoDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Lihua ZhuInstitute of Clinical, Jiangsu Health Vocational College, Nanjing, China.
Shun WuDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Yan ZhouDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Yi ZhangDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Bangbang LiDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Lili LinDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Jingjing MaDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Qianying GuDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Jiaping ShuDepartment of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Zhongda Hospital Southeast University · CNJiangsu Vocational College of Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNA (LncRNA) has high expression in the brain. Animal studies have shown that lncRNA plays an important role in brain functions and mediates the development of many neurological diseases. However, data on the expression of lncRNAs and the clinical significance in prematurely born infants with diseases such as periventricular white matter damage (PWMD) remains scant. Here, we compared the expression of the lncRNAs in whole blood samples obtained from prematurely born infants with PWMD with samples from prematurely born infants without PWMD. Our data demonstrated differential expression of the lncRNAs between the two groups. Further, we showed that the lncRNAs play important roles in the development of PWMD. Our findings give insights into the functions of the lncRNAs in PWMD and provide evidence for the improvement of diagnostic and treatment strategies in infants with PWMD.

Indexed as

human bloodlong non-coding RNAperiventricular white matter damagepremature infantsRNA sequencing

Identifiers

PMID33995480
PMCPMC8120246
OpenAlexW3158909745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.