Evidence map›Paper›PMID 33995406›Full record

ArticleFrontiers in immunology2021

Single-Cell Transcriptional Heterogeneity of Neutrophils During Acute Pulmonary

M Elizabeth Deerhake, Estefany Y Reyes, Shengjie Xu-Vanpala, Mari L Shinohara

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Multi‑omics reveal neutrophil heterogeneity in sepsis (Review).International journal of molecular medicine · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Inbred Mouse Models inJournal of fungi (Basel, Switzerland) · 2024
    Review
  11. Article
  12. Review
  13. Lung Epithelial Cell Line Immune Responses toJournal of fungi (Basel, Switzerland) · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

M Elizabeth DeerhakeDepartment of Immunology, Duke University School of Medicine, Durham, NC, United States.
Estefany Y ReyesDepartment of Immunology, Duke University School of Medicine, Durham, NC, United States.
Shengjie Xu-VanpalaDepartment of Immunology, Duke University School of Medicine, Durham, NC, United States.
Mari L ShinoharaDepartment of Immunology, Duke University School of Medicine, Durham, NC, United States.
Duke University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Role of osteopontin in innate immunity during infections and inflammationR01AI088100 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2011 to 2021
$4.3M
Basic Immunology Training ProgramT32AI052077 · NIAID · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2002 to 2024
$4.2M
Heterogeneous immune responses of the alveolar macrophage population during pulmonary fungal infectionsR01AI160737 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2021 to 2025
$2.7M
Protective role of Clec7a/dectin-1 in CNS autoimmunityR01NS120417 · NINDS · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2021 to 2025
$2.0M
Protective role of dectin-1 signaling in an animal model of Multiple SclerosisF30AI140497 · NIAID · DUKE UNIVERSITY · PI DEERHAKE, MARION ELIZABETH · 2018 to 2021
$169k
NIAID NIH HHS F30 AI140497NIAID NIH HHS R01 AI088100NIAID NIH HHS R01 AI160737NIAID NIH HHS T32 AI052077NIGMS NIH HHS T32 GM145449NINDS NIH HHS R01 NS120417
6 · The paper itself

Abstract

Neutrophils are critical as the first-line defense against fungal pathogens. Yet, previous studies indicate that neutrophil function is complex during

Indexed as

AnimalsCryptococcosisCryptococcus neoformansCytokinesLung Diseases, FungalMiceNeutrophil ActivationNeutrophilsOxidative StressReactive Oxygen SpeciesSingle-Cell AnalysisCytokinesReactive Oxygen SpeciesCryptococcus neoformansfungal infectionheterogeneityneutrophilspulmonarysingle-cell RNA sequencing (scRNA-seq)

Identifiers

PMID33995406
PMCPMC8116703
OpenAlexW3158552470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.