Evidence map›Paper›PMID 33995399›Full record

ReviewFrontiers in immunology2021

How Microbes Defend Themselves From Incoming Hydrogen Peroxide.

Ananya Sen, James A Imlay

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
8.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 137 citations in OpenAlex.

  1. S267P mutation of OxyR regulator inSynthetic and systems biotechnology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Detoxification of host-relevant HbioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Understanding Iron and Oxidative Stress Response inbioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Article
  16. Factors governing the response ofFrontiers in cellular and infection microbiology · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ananya SenDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
James A ImlayDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
University of Illinois Urbana-Champaign · US

Funding

The Physiology of Oxidative Stress in Escherichia coliR01GM049640 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI IMLAY, JAMES A. · 1994 to 2024
$6.9M
NIGMS NIH HHS R01 GM049640
6 · The paper itself

Abstract

Microbes rely upon iron as a cofactor for many enzymes in their central metabolic processes. The reactive oxygen species (ROS) superoxide and hydrogen peroxide react rapidly with iron, and inside cells they can generate both enzyme and DNA damage. ROS are formed in some bacterial habitats by abiotic processes. The vulnerability of bacteria to ROS is also apparently exploited by ROS-generating host defense systems and bacterial competitors. Phagocyte-derived

Indexed as

BacteriaBacterial ProteinsHydrogen PeroxideOxidation-ReductionReactive Oxygen SpeciesSuperoxidesTranscription FactorsBacterial ProteinsHydrogen PeroxideReactive Oxygen SpeciesSuperoxidesTranscription Factorsnitric oxideOxyR regulatorperoxide sensing repressor (PerR)reactive oxygen speciesYap1p

Identifiers

PMID33995399
PMCPMC8115020
OpenAlexW3158445185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.