Evidence map›Paper›PMID 33995355›Full record

ArticleFrontiers in immunology2021

Physiological Sympathetic Activation Reduces Systemic Inflammation: Role of Baroreflex and Chemoreflex.

Fernanda Brognara, Jaci Airton Castania, Alexandre Kanashiro, Daniel Penteado Martins Dias, Helio Cesar Salgado

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Carbidopa: beyond Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Similar Patterns of Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue and Post-COVID-19 Syndromes.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Article
  12. Review
  13. Deep Phenotyping of Neurologic Postacute Sequelae of SARS-CoV-2 Infection.Neurology(R) neuroimmunology & neuroinflammation · 2023
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Fernanda BrognaraDepartment of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Jaci Airton CastaniaDepartment of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Alexandre KanashiroDepartment of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Daniel Penteado Martins DiasBarão de Mauá University Center, Ribeirão Preto, Brazil.
Helio Cesar SalgadoDepartment of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Universidade de São Paulo · BRCentro Universitário Barão de Mauá · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Baroreflex and chemoreflex act through the autonomic nervous system, which is involved with the neural regulation of inflammation. The present study reports the effects of reflex physiological sympathetic activation in endotoxemic rats using bilateral carotid occlusion (BCO), a physiological approach involving the baroreflex and chemoreflex mechanisms and the influence of the baroreceptors and peripheral chemoreceptors in the cardiovascular and systemic inflammatory responses. After lipopolysaccharide (LPS) administration, the arterial pressure was recorded during 360 min in unanesthetized rats, and serial blood samples were collected to analyze the plasma cytokine levels. BCO elicited the reflex activation of the sympathetic nervous system, providing the following outcomes: (I) increased the power of the low-frequency band in the spectrum of the systolic arterial pressure during the BCO period; (II) reduced the levels of pro-inflammatory cytokines in plasma, including the tumor necrosis factor (TNF) and the interleukin (IL)-1

Indexed as

AnimalsAutonomic Nervous SystemBaroreflexBlood PressureChemoreceptor CellsEndotoxemiaInflammationInterleukin-10Interleukin-1betaLipopolysaccharidesPressoreceptorsRatsRats, WistarSympathetic Nervous SystemTumor Necrosis Factor-alphaIL1B protein, ratInterleukin-10Interleukin-1betaLipopolysaccharidesTumor Necrosis Factor-alphabaroreceptorsbilateral carotid occlusionchemoreceptorsinflammationneuroimmune interactionssympathetic activation

Identifiers

PMID33995355
PMCPMC8117744
OpenAlexW3159489286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.